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IRCT2015122512823N3 IRCT 2016-01-04 Semnan University of Medical Sciences The effect of the treatment of periodontitis on rheumatoid arthritis disease activity The effect of the treatment of periodontitis on rheumatoid arthritis disease activity in patients who referred to Rheumatology clinic, Semnan 2016-01-05 anticipated 30 Complete https://irct.ir/trial/12828 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Supportive. 3 Condition 1: Periodontitis. Condition 2: Rheumatoid arthritis. Interventions: At first, DAS-28 questionnaire filled and if periodontitis confirmed by dentist, treatment initiated which is includes non surgical scaling, root planning, systemic antibiotics (metronidazole 500 mg three time per day and amoxicillin 500 mg three time per day for a ten days period), antiseptic (Chlorhexidine gluconate oral rinse 0.12% 2 time per day) and oral health education. At the end of treatment period, on 20th day of study all patients will be visited by dentist and if he confirm complete remission, on days 45 and 90 after initiation all patients will be visited by rheumatologist and DAS-28 questionnaire completed again. ESR and CRP are also measured at each visit in a reference laboratory. Background: Many patients with rheumatoid arthritis (RA), which is one of the most common inflammatory diseases, at the same time, suffer from periodontitis. Since some studies have shown a common biochemical link between the synchronicity of these two diseases, we decided to investigate the effects of periodontal therapy on disease activity in RA.<br /> Materials and Methods: In this quasi-experimental study, 30 patients with simultaneous RA and periodontitis referred to the rheumatology clinic in Semnan from March 2014 to February 2016 were selected through census method. Disease activity score uses 28 joint counts (DAS28) questionnaires were completed and referred to executive dentist of the project. Patients with confirmed periodontitis were received treatments including non-surgical scaling, Root planning, systemic antibiotics (10-day period, capsules of amoxicillin and metronidazole, 3 per day) and chlorhexidine as well as oral health education. Then, at days 45 and 90 after treatment, the patients were visited by a rheumatologist and DAS28 questionnaire was again completed. ESR and CRP of each visit were evaluated in reference laboratories at Semnan University of Medical Sciences.<br /> Results: the evaluation of 30 patients with mean age of 50.2±10.62 years (80% female) showed that the difference in the level of disease activity between baseline versus 45 days later (5.18±0.092 vs 4.02±1.22, p
public Dr. Jamileh Moghimi
Kowsar Hospital, Basidj Boulevard, Amin Avenue
Semnan Iran (Islamic Republic of) 3519899951 +98 23 3343 7821 moghimi_jam@yahoo.com Semnan University of Medical Sciences scientific Dr. Jamileh Moghimi
Kowsar hospital, Amin Avenue, Basidj Boulevard
Semnan Iran (Islamic Republic of) 3519899951 +98 23 3343 7821 moghimi_jam@yahoo.com Semnan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: 18 years and older; diagnosis of RA at least one year ago; disease activity score between 3.2 and 5.1; having at least six natural teeth; the patient be educable; having gingivitis with mild to moderate degree. The exclusion criteria were: risk of infection; serious liver or kidney diseases; chronic infectious disease that needs to frequent use of antibiotics; uncontrolled diabetes; taking anti-thrombotic and biologic therapy; sensitivity to chlorhexidine gluconate (oral rinse); contraindication of amoxicillin and metronidazole; severe oral problems which requiring immediate surgery; pregnancy, breast-feeding or if want to get pregnant during the study period; any febrile or chronic diseases. no limit no limit Both K05.3 M06.9 Chronic periodontitis Rheumatoid arthritis, unspecified Treatment - Other Interventions: At first, DAS-28 questionnaire filled and if periodontitis confirmed by dentist, treatment initiated which is includes non surgical scaling, root planning, systemic antibiotics (metronidazole 500 mg three time per day and amoxicillin 500 mg three time per day for a ten days period), antiseptic (Chlorhexidine gluconate oral rinse 0.12% 2 time per day) and oral health education. At the end of treatment period, on 20th day of study all patients will be visited by dentist and if he confirm complete remission, on days 45 and 90 after initiation all patients will be visited by rheumatologist and DAS-28 questionnaire completed again. ESR and CRP are also measured at each visit in a reference laboratory Rheumatoid arthritis activity. Timepoint: Before initiation of interventions, 45 and 90 days after intervention. Method of measurement: DAS-28 questionnaire. Erythrocyte Sedimentation Rate. Timepoint: Before initiation of interventions, 45 and 90 days after intervention. Method of measurement: Laboratory test. C- reactive protein. Timepoint: Before initiation of interventions, 45 and 90 days after intervention. Method of measurement: Laboratory test. Semnan University of Medical Sciences Approved 2015-12-01 Ethical Commettee of Semnan University of Medical Sicenses Basidj Boulevard Semnan Iran (Islamic Republic of)