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IRCT2016012312847N2 IRCT 2016-03-02 Vice Chancellor for research of Shahid Sadooghi University Of Medical Sciences Comparison of Benzydamine HCl 0.15% mouthwash and Ibuprofen effect on pain relief after crown lengthening, a clinical trial Comparison of Benzydamine HCl 0.15% mouthwash and Ibuprofen effect on pain relief after crown lengthening, a clinical trial 2016-02-04 anticipated 36 Complete https://irct.ir/trial/12869 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Other design features: Table of random numbers. N/A crown lengthing surgery. Intervention 1: Intervention group: rinse with benzydamine hydrochloride mouthwash 0.15% (the pharmaceutical company "Exir" Boroujerd) at a rate of once every 3 hours 15 ml for 30 seconds in mouth. Intervention 2: Control group: consume ibuprofen 400 mg tablets every 6 hours (the pharmaceutical company "Hakim").
public Arezoo Khbazian
Dahe Fajr Blv, Yazd
Yazd Iran (Islamic Republic of) +98 35 3625 0395 arezookhabazian@yahoo.com; roseinthepalace@ymail.com Shahid Sadooghi University Of Medical Sciences scientific Arezoo Khabazian
Dahe Fajr Blv, Yazd
Yazd Iran (Islamic Republic of) +98 35 3625 0395 arezookhabazian@yahoo.com Shahid Sadooghi University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Periodontal health establishment؛ require crown lengthening surgery in the posterior teeth؛ avoiding the use of any painkiller or anti-inflammatory or Counter during the last 6 months؛ lack of systemic problems؛ lack of contraindications of ibuprofen or Benzydamine hydrochloride mouthwash. Benzydamine hydrochloride contraindications include hypersensitivity to the drug or formulation components؛ children under 12 years of age؛ past medical history and feed intake. Warning of eye contact with the drug. The classification used in pregnancy؛ is in category C. It should not be administered to a patient more than 7 days؛ and in case of allergies؛ medication should be discontinued. Information on medication safety in nursing mothers. Contraindications Ibuprofen include third trimester of pregnancy (the drugs X)؛ such as anaphylaxis or Angioedema history of severe allergic reaction caused by aspirin or other non steroidal anti-inflammatory drugs or nose polyp with spasticity due to an inflammatory disease or ulcerative the upper or lower gastrointestinal tract ؛ hemophilia and other blood disorders؛ including disorders of hemostasis؛ or platelets؛ kidney disorders ؛ stomatitis and elderly patients and patients the risk of gastrointestinal bleeding and ulcers in them is high. Concomitant use of ibuprofen with inhibitors of angiotensin converting enzyme (ACE)؛ one of the quinolone antibacterial agents؛ hypoglycemic sulfonylurea drugs؛ cyclosporine؛ lithium and methotrexate may؛ anticoagulants or thrombolytic؛ triamterene؛ valproic acid؛ aspirin and performance they interference is increasing or decreasing. Exclusion criteria: Unwillingness to participate in the plan؛ effective pain medications (analgesics or anti-inflammatory drug or drug) during the last 6 months؛ the risk of systemic problems affecting the periodontal tissues (diabetes؛ hypertension and heart disease؛ vascular)؛ ibuprofen is contraindicated or mouthwash Benzydamine hydrochloride. no limit no limit Both Treatment - Drugs Treatment - Drugs Intervention group: rinse with benzydamine hydrochloride mouthwash 0.15% (the pharmaceutical company "Exir" Boroujerd) at a rate of once every 3 hours 15 ml for 30 seconds in mouth. Control group: consume ibuprofen 400 mg tablets every 6 hours (the pharmaceutical company "Hakim"). Pain. Timepoint: 24 hours after intervention. Method of measurement: Visual Analog Scale. Stingling & numbness. Timepoint: 24 hours after intervention. Method of measurement: asking from patient. 000 000 Vice Chancellor for research of Shahid Sadooghi University Of Medical Sciences Approved 2015-06-21 Ethics committee of Shahid Sadooghi University Of Medical Sciences Dahe Fajr Blv, Yazd Yazd Iran (Islamic Republic of)