IRCT2013041613027N1 IRCT 2013-05-07 Research adjutancy ,Guilan university of medical sciences The effect of Donepezil and Memantine combinition on treatment of traumatic brain injury The Comparative study about effect of Donepezil with and without Memantine on recovery of cognitive, linguistic dysfunctions and disability rating in traumatic brain injury patients during the subacute phase 2013-09-22 anticipated 162 Complete https://irct.ir/trial/12977 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Traumatic brain injury. Intervention 1: Drug intervention of Donepezil without Memantine in dosage of 5 mg during 1 month then induction of drug dosage to 10 mg for 2 months . in first 1 month for Donepezil group one tablet of 5 mg Donepezil and half tablet Memantin placebo at evening,whereas, next 2 months for Donepezil group one tablet of Donepezil 10 mg and half tablet of Memantine placebo at evening and half tablet of Memantin placebo at morning,. Intervention 2: Drug intervention of Donepezil with Memantine carries out in dosage of 5 mg for each of them during 1 month then will be continued by induction of drug dosage to 10 mg for 2 months. In combined group (Donepezil+Memantine) is offered one tablet of Donepezil 5 mg and half tablet of Memantine 10 mg at evening in first 1 month. Whereas, next 2 months this group is used one tablet of Donepezil 10 mg and half tablet of Memantine 10 mg at evening and half tablet of Memantine 10 mg at morning. Intervention 3: Control group receive placebo similar to Memantin and Donepezil. in first 1 month one and half tablet of placebo is used daily(one tablet of Donepezil placebo and half tablet of Memantine placebo at evening) in next 2 month 2 tablet of placebo is used daily (one tablet of Donepezil placebo at evening and half tablet of Memantin placebo at morning and half other at evening) .