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IRCT2013042713140N1 IRCT 2013-05-19 Isfahan University of Medical Sciences Comparing Pain & Swelling after Surgical Extraction of Mandibular Third Molar in Intra-oral Dexamethasone Injection and without it Comparing Pain and Swelling after Surgical Extraction of Mandibular Third Molar in Dexamethasone Injection to Medial Pterygoid and without Corticosteroid Method 2013-04-28 anticipated 60 Complete https://irct.ir/trial/13060 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. N/A Oral health. Intervention 1: For the case group, after the inferior alveolar block injection and before starting the surgery, single dose of dexamethasone (8mg) will injected into medial pterygoid and pterygomandibular space. Intervention 2: For the control group after inferior alveolar block injection, the surgical removal of impacted third mandibular molar will done using no corticosteroid.
public Shiarani Mohammadjavad
Department of oral and maxillofacial surgery, Faculty of Dentistry, Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) 81745-319 +98 38 2422 5600 javaad.sh_f@yahoo.com Faculty of Dentistry, Isfahan University of Medical Sciences scientific Movahedian Bijan
Department of oral and maxillofacial surgery, Faculty of Dentistry, Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) 81745-319 +98 31 1792 2854 b_movahedian@dnt.mui.ac.ir Isfahan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: non pregnant participants have single impacted mandibular third molar in healthy and without pericoronitis manner. They must have no contra-indication for injection of the corticosteroid and lidocaine with epinephrine and also, should not medicated by any possibly bias maker drug. Type of the impaction, must not provide sever difficulty. The participants should be mentally at healthy level and provide written informed consent to incorporate in the study. Exclusion criteria: unwilling participants to continue the study and those with abnormality of wound healing process. 18 years 35 years Both Z00-Z99 Factors influencing health status and contact with health services Treatment - Drugs N/A For the case group, after the inferior alveolar block injection and before starting the surgery, single dose of dexamethasone (8mg) will injected into medial pterygoid and pterygomandibular space For the control group after inferior alveolar block injection, the surgical removal of impacted third mandibular molar will done using no corticosteroid Pain. Timepoint: 48 hours and one week after intervention. Method of measurement: Visual analogue scale of pain- Number of reqiered analgesics tablets. Swelling. Timepoint: 48 hours and one week after intervention. Method of measurement: Questionnaire. Trismus. Timepoint: 48 hours and one week after intervention. Method of measurement: Maximum mouth-opening. General patients' satisfaction. Timepoint: 48 hours and one week after intervention. Method of measurement: Visual analogue scale for satisfaction. Quality of life. Timepoint: 96 hours and one week after intervention. Method of measurement: Questionnaire. Trismus. Timepoint: During the study. Method of measurement: Maximum mouth opening- Patienits complaint. Isfahan University of Medical Sciences Approved 2013-04-25 Isfahan Regional Bioethics Committee University of Medical Sciences. Hezar-Jarib Ave Isfahan Iran (Islamic Republic of)