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IRCT2014090813156N7 IRCT 2014-12-30 Research Centre of Mazandaran Univeristy of Medical Sciences Effect of amiodarone in postoperative atrial fibrillation after coronary artery bypass surgery amiodarone Effect of prophylactic amiodarone in the prevention of postoperative atrial fibrillation after coronary artery bypass surgery in Mazandaran Heart Center 2014-11-22 anticipated 150 Complete https://irct.ir/trial/13083 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 CAD in CABG. Intervention 1: Control group: in this group use placebo (structured by normal saline serum) that similiar to Amiodarone Ampules and tablets. according to this research, anesthesia and patient do not inform about infusion, so two blind research have. in OR; two times infuse placebo and after that in ICU ward infuse drip in 24 hrs, then oral placebo are fed until discharge. Preoperative and Postoperative atrial size and ejection fraction measured. Intervention 2: Amiodarone: Amiodarone vial 2 vials 2 ml ampoules equivalent to 300 mg amiodarone, the surgical incision during a time period of 20 minutes through a central venous catheter, and the next dose as DrIp ICUOH within 24 hours by weight will receive 20 mg per kg. Preoperative and Postoperative atrial size and ejection fraction measured.
public Kaveh Jafari
Nasibeh nursing School, Vesal street
Sari Iran (Islamic Republic of) +98 911 780 7886 kavehjafari@yahoo.com Mazandaran University of Medial Sciences scientific Kaveh Jafari
Nasibeh Nursing School, Vesal Street
Sari Iran (Islamic Republic of) +98 911 780 7886 kavehjafari@yahoo.com Mazandaran University of Medial Sciences Iran (Islamic Republic of) Inclusion criterion: preoperative sinus rhythm. Exclusion criteria: allergy to amiodarone or use of amiodarone in the last 6 months; history of toxicity with amiodarone, anti-arrhythmic therapy before surgery; thyroid disease; aspartate aminotransferase or alanine aminotransferase concentration 4 times higher than normal; pregnant patients, a lower rate 50; heart failure; AV block and surgical history of lung disease and hepatitis. no limit no limit Both T82.2 Mechanical complication of coronary artery bypass and valve grafts Placebo Treatment - Drugs Control group: in this group use placebo (structured by normal saline serum) that similiar to Amiodarone Ampules and tablets. according to this research, anesthesia and patient do not inform about infusion, so two blind research have. in OR; two times infuse placebo and after that in ICU ward infuse drip in 24 hrs, then oral placebo are fed until discharge. Preoperative and Postoperative atrial size and ejection fraction measured Amiodarone: Amiodarone vial 2 vials 2 ml ampoules equivalent to 300 mg amiodarone, the surgical incision during a time period of 20 minutes through a central venous catheter, and the next dose as DrIp ICUOH within 24 hours by weight will receive 20 mg per kg. Preoperative and Postoperative atrial size and ejection fraction measured The incidence of atrial fibrillation. Timepoint: During hospitalization. Method of measurement: Monitoring. Hospitalization time. Timepoint: During hospitalization. Method of measurement: Monitoring and documentation. Research Centre of Mazandaran Univeristy of Medical Sciences Approved 2014-11-19 Mazandaran University of Medical Sciences Vice chancellor foe research, Mazandaran University of Medical Sciences Sari Iran (Islamic Republic of)