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IRCT2015101613181N2 IRCT 2015-11-17 Isfahan University of Medical Sciences Evaluation of the Effect of intravenous paracetamol on perioperative pain in coronary artery bypass graft surgery Evaluation of effect of paracetamol on post-operative pain in coronary artery bypass graft surgery 2014-05-31 anticipated 110 Complete https://irct.ir/trial/13129 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. N/A Perioperative pain. Intervention 1: In paracetamol group 15 minutes before induction of anesthesia 1 g intravenous paracetamol in 50 cc normal saline solution was infused to the patient within 15 minutes. Next dose of paracetamol was 1 g which was infused intravenously over 15 minutes within 6-4 hours after the first dose, so that the injection time was during the last 20 minutes of surgery. Then subsequent doses of paracetamol, every 6 hours for 3 days was injected in intensive care at a rate of 1 g. Intervention 2: In the control group at all stages of paracetamol injection instead of paracetamol equal volume of normal saline was used.
public Mojtaba Mansouri
Isfahan Univrsity of Medical Sciences
Isfahan Iran (Islamic Republic of) +98 31 3775 0252 mansouri@med.mui.ac.ir Isfahan Univrsity of Medical Sciences scientific Mojtaba Mansouri
Isfahan Univrsity of Medical Sciences
Isfahan Iran (Islamic Republic of) +98 31 3775 0252 mansouri@med.mui.ac.ir Anesthesiology and Critical Care Research Center, Department of Anesthesiology Iran (Islamic Republic of) Inclusion Criteria: Inclusion criteria for the study were: undergoing elective surgery CABG, the individual agreement to participate in the study, age 40 to 70 years, not having liver failure (Serum bilirubin greater than 1.8 mg per deciliter and aspartate and alanine aminotransfraz more than 1.5 times of the upper limit of normal), not having renal failure (serum creatinine greater than 2 mg per deciliter), not addictive to opioid drugs and psychotropic substances, and having cardiac ejection fraction greater than 30%., Exclusion criteria for the study: Excessive bleeding after surgery (more than 150 ml for the first two hours), having other surgeries in addition to coronary artery bypass surgery such as repair or replacement of heart valves, repeated surgery, and the need for aortic balloon support. 40 years 70 years Both T82.8 Other specified complications of cardiac and vascular prosthetic devices, implants and grafts Prevention Prevention In paracetamol group 15 minutes before induction of anesthesia 1 g intravenous paracetamol in 50 cc normal saline solution was infused to the patient within 15 minutes. Next dose of paracetamol was 1 g which was infused intravenously over 15 minutes within 6-4 hours after the first dose, so that the injection time was during the last 20 minutes of surgery. Then subsequent doses of paracetamol, every 6 hours for 3 days was injected in intensive care at a rate of 1 g. In the control group at all stages of paracetamol injection instead of paracetamol equal volume of normal saline was used. Pain. Timepoint: during study. Method of measurement: VAS and FAS. Isfahan University of Medical Sciences Approved 2013-08-20 IsfahanUniversity of Medical Sciences Hezar Jarib st. Isfahan Iran (Islamic Republic of)