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IRCT2015092413566N6 IRCT 2016-01-13 Tabriz University of Medical Sciences-Deputy of Research and Technolog Effect of Celery and Anise on oligomenorrhea Comparison of Traditional Iranian Medicine product (based on Celery and Anise seed) with metformin on oligomenorrhea in patients with polycystic ovary syndrome(PCOs) 2016-01-05 anticipated 72 Complete https://irct.ir/trial/13384 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Polycystic ovarian syndrome. Intervention 1: Intervention group:In the group receiving traditional medicine products,patient will use 4.5 g celery and anise powder (6 capsules divided into 3 meals ) for two weeks. If the menstruation occurs at each stage of using the drug, the herbal drug will cut and one placebo capsule will be used after every meal. After purity, restart the herbal medication and this process is repeated 3 cycles. Intervention 2: Control group:In the group taking metformin,1500 mg metformin powder(6 capsules divided into 3 meals) for two weeks . In the menstruation days and the menstruation waited days,one metformin powder(500mg) capsule will be used.After purity,1500 mg metformin powder(6 capsules divided into 3 meals)repeatedly will be prescribed and this process is repeated 3 cycles.
public Arezoo Moini Jazani
Tabriz.Azadi street.Golgasht street.Tabriz University.in front of the Faculty of Mathematics.upper class of Central Library of Tabriz University of Medical Sciences.School of Traditional Medicine.
Tabriz Iran (Islamic Republic of) 5166737618 +98 41 3337 9529 Moeinia@tbzmed.ac.ir dr.moeeni@yahoo.com School of Traditional Medicine-Tabriz University of Medical Sciences scientific Dr.Kobra Hamdi
Tabriz- South Army street-Baghshomal crossroad-Al-Zahra hospital- Infertility ward
Tabriz Iran (Islamic Republic of) 5166737618 +98 41 3553 9161 HamdiK@tbzmed.ac.ir Hamdi_kobra@yahoo.com Tabriz University of Medical Sciences- Al-Zahra hospital Iran (Islamic Republic of) Inclusion criteria: patients satisfaction , Patients with PCOS that their main complaint is oligomenorrhea, age 40-18 years, no pregnancy, no abortion or within 6 weeks post partum; lack of breastfeeding, absence of any systemic diseases such as hyperinsulinemia and hyperandrogenism, diabetes, Cushing's syndrome, congenital adrenal hyperplasia, hyperprolactinemia, thyroid disorders, body mass index between 18 and 35 kg / m2; non-hormonal drugs in the last month, lack of uterine malignancies, ovarian and other malignancies;lack of Chronic liver disease and kidney failure, lack of headaches and epilepsy; willingness to participate in the study. Exclusion criteria: use of hormonal drugs during the study, the incidence of side effects, the need for other interventions and surgery, pregnancy during the study, patient request for exclusion. 18 years 40 years Female E28.2 Polycystic ovarian syndrome Treatment - Drugs Treatment - Drugs Intervention group:In the group receiving traditional medicine products,patient will use 4.5 g celery and anise powder (6 capsules divided into 3 meals ) for two weeks. If the menstruation occurs at each stage of using the drug, the herbal drug will cut and one placebo capsule will be used after every meal. After purity, restart the herbal medication and this process is repeated 3 cycles. Control group:In the group taking metformin,1500 mg metformin powder(6 capsules divided into 3 meals) for two weeks . In the menstruation days and the menstruation waited days,one metformin powder(500mg) capsule will be used.After purity,1500 mg metformin powder(6 capsules divided into 3 meals)repeatedly will be prescribed and this process is repeated 3 cycles. Experience of menstural bleeding. Timepoint: Before intervention and 1,2, 3, 4 month after intervention. Method of measurement: Ask the patient and complete tracking form. Duration of bleeding. Timepoint: Before intervention and 1,2,3, 4 month after intervention. Method of measurement: Ask the patient and complete tracking form. Menstrual blood volume. Timepoint: Before intervention and1,2, 3, 4 month after intervention. Method of measurement: Pictorial Blood Loss Assessment Chart (PBAC). Menstrual cycle length. Timepoint: Before intervention and1,2, 3, 4 month after intervention. Method of measurement: Ask the patient and complete tracking form. Serum LH. Timepoint: Before intervention and 3 month after intervention. Method of measurement: Serum analysis by ELIZA. LH/FSH proportion. Timepoint: Before intervention and 3 month after intervention. Method of measurement: Serum analysis by ELIZA. Free Testosterone. Timepoint: Before intervention and 3 month after intervention. Method of measurement: Serum analysis by ELIZA. Fasting Blood Suger(FBS). Timepoint: Before intervention and 3 month after intervention. Method of measurement: blood biochemistrical analysis. Liver function test(AST,ALT). Timepoint: Before intervention and 3 month after intervention. Method of measurement: spectophotometry. Tabriz University of Medical Sciences-Deputy of Research and Technolog Approved 2015-09-14 Tabriz University of Medical Sciences- Deputy of research and technology-Ethic committee Tabriz-Gogasht street, Tabriz University of Medical Sciences-Central Building number 2-third floor-Deputy of research and technology Tabriz Iran (Islamic Republic of)