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IRCT2014012713690N2 IRCT 2014-03-08 Vice chancellor for research affairs of Shiraz University of Medical Science Effect of zinc sulphate on mucositis. Comparison between zinc sulphate and placebo capsules in the prevention of mucositis in patients with leukemia under chemotherapy: a clinical trial study 2012-04-01 anticipated 86 Complete https://irct.ir/trial/13474 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 2 leukaemia. Intervention 1: Intervention group: administration of 50 mg zinc sulphate capsule, three times daily for 14 days from the first day of chemotherapy. Intervention 2: Control group: administration of placebo capsules, three times daily for 14 days from the first day of chemotherapy.
public Masoume Rambod
Nursing and Midwifery University, Namazee Sq, Zand Ave, Shiraz
Shiraz Iran (Islamic Republic of) +98 71 1647 4258 rambodm@sums.ac.ir Shiraz University of Medical Science scientific Masoume Rambod
Nursing and Midwifery University, Namazee Sq, Zand Ave, Shiraz
Shiraz Iran (Islamic Republic of) +98 71 1647 4258 rambodm@sums.ac.ir Shiraz University of Medical Science Iran (Islamic Republic of) The inclusion criteria of the study were leukemia patients with 18 years old or above, under chemotherapy, be alerted and oriented, and able to swallow capsule and did not show the mucositis symptoms such as ulcers, erythema, oedema, painful and dysphasia.The patients with any ulcer in their mouth, pregnant and lactating women, individuals under head and neck radiotherapy and patients who had the allergic to zinc were excluded from the study. 18 years 100 years Both C91, C92 Lymphoid leukaemia, Myeloid leukaemia Prevention Prevention Intervention group: administration of 50 mg zinc sulphate capsule, three times daily for 14 days from the first day of chemotherapy. Control group: administration of placebo capsules, three times daily for 14 days from the first day of chemotherapy. Mucositis. Timepoint: Fourth, seventh,14th day from starting chemotherapy. Method of measurement: JP Donnelly and Colleagues questionnaire, and World Health Organization mucositis scale. Vice chancellor for research affairs of Shiraz University of Medical Science Approved 2010-02-01 Ethics committee of Shiraz University of Medical Science Vice chancellor for research affairs, seven floor, Shiraz University of Medical Science, beside Helal Ahmar, Zand Ave, Shiraz, Iran Shiraz Iran (Islamic Republic of)