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IRCT2014113013739N3 IRCT 2015-02-15 Vice chancellor for research, Tehran University of Medical Sciences (Major supporter) Effect of sodium mannuronate ointment in osteoarthritis treatment Comparison of clinical effects of sodium mannuronate and salicylate ointments in the reduction of activity and symptoms of disease in patients with osteoarthritis 2014-12-22 anticipated 50 Complete https://irct.ir/trial/13518 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Osteoarthritis. Intervention 1: Control group will be treated topically 3 times per day for 30 days with Salicylate ointment produced by Sobhan Darou Co. Intervention 2: Treatment group will be treated topically 3 times per day for 30 days with non-steroidal ointment called Mannuronate sodium which its effective material has been produced in department of immunology, Tehran University of Medical Sciences and then is packaged by Tropical Drug Industry Kish Co.
public Abbas Mirshafiey
Tehran University of Medical Sciences
Tehran Iran (Islamic Republic of) +98 21 8895 4913 mirshafiey@tums.ac.ir Tehran University of Medical Sciences scientific Abbas Mirshafiey
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences
Tehran Iran (Islamic Republic of) +98 21 8896 4913 mirshafiey@tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients with osteoarthritis in the age range of 35 to 75 years, according to the diagnostic criteria of American College of Rheumatology which at the first visit by a specialist in rheumatology and then by laboratory and radiological parameters are diagnosed. Exclusion criteria: history of fever and infectious diseases, pregnancy and breast feeding, other autoimmune diseases, cancers and malignancies, the involvement of patients in the other clinical trials during the past 4 weeks, other diseases simultaneously (hepatic, nephrotic, hematologic, gastrointestinal, endocrine, cardiovascular, respiratory, neurologic or cephalic) 35 years 75 years Both M15.0 Polyartherosis Treatment - Drugs Treatment - Drugs Control group will be treated topically 3 times per day for 30 days with Salicylate ointment produced by Sobhan Darou Co. Treatment group will be treated topically 3 times per day for 30 days with non-steroidal ointment called Mannuronate sodium which its effective material has been produced in department of immunology, Tehran University of Medical Sciences and then is packaged by Tropical Drug Industry Kish Co. Osteoarthritis activity. Timepoint: Before intervention and one month after intervention. Method of measurement: Questionnaire. Pain. Timepoint: Before intervention and one month after intervention. Method of measurement: Questionnaire. Stiffness. Timepoint: Before intervention and one month after intervention. Method of measurement: Questionnaire. Physical performance. Timepoint: Before intervention and one month after intervention. Method of measurement: Questionnaire. Vice chancellor for research, Tehran University of Medical Sciences (Major supporter) Approved 2014-11-22 Ethics Committee of Tehran University of Medical Sciences Tehran University of Medical Sciences, Poursina Street, Keshavarz Blvd Tehran Iran (Islamic Republic of)