Tuberculosis (TB) is one of the main causes of death in the world, especially Asia. Much morbidity and mortality due to tuberculosis occur in developing countries which smoking it is very common in them. New research on various aspects of the relationship between smoking and tuberculosis protests has shown effect of smoking on clinical, bacteriological, treatment and recurrence of tuberculosis. Therefore, smoking is a significant risk factor for tuberculosis and tobacco control, so it is recommended to include smoke cessation intervention as a preventive intervention in tuberculosis control programs.
This Randomized Clinical trial (RCT) will be conducted during 3 years at National Research Institute of Tuberculosis and Lung Disease (NRITLD) in Tehran.
During the study, approximately 60 patients in each group should be studied. Thus, in total, 240 patients (60 patients in each arm) will be evaluated for this study.Patients will be randomly selected among new TB diagnosed Cases, who will be treated by DOTS regime. Smoking evaluation and cessation Counseling and will be offered to the Patients by Physician trained in Smoke Cessation.
Patients will be divided randomly in to the intervention group and will receive related smoke cessation intervention. Patients will be followed for Smoke Cessation result at the end of second week, second, quarter and Sixth months.
Immunologic evaluation included measurement of cytokine (IL-8) and Fogocytosis will be done at base line and at the end of fourth month. TB Treatment assessment will be done at the end of second, fourth and sixth months, base on negative sputum smear, in all of the study groups.