IRCT2013062613783N1 IRCT 2013-08-31 Shahid Beheshti University of Medical Sciences Determining efficacy of smoke cessation on tuberculosis treatment Determining efficacy of smoke cessation program on quit Rate, immunological response and treatment outcome in new pulmonary tuberculosis patients: a clinical trial 2013-08-23 anticipated 240 Complete https://irct.ir/trial/13562 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A tuberculosis. Intervention 1: Intervention group (cessation consultation and pharmacotherapy ): smokers patients with pulmonary tuberculosis who are under Tb DOTS Treatment that recieve smoke cessation program consultation and pharmacotherapy . Cessation consultation consist of advice , assist and arrange .Four counseling sessions will be held during the first two weeks .patients will also receive sustain release Bupropion -150 mg- BD for nine weeks which will be free of charge for them. Intervention 2: Intervention groups(Brief advice counseling): smokers patients with pulmonary tuberculosis who are under Tb DOTS Treatment that receive smoking cessation brief advice for three minute. This group will get a short brief advice; strongly and clearly advice to quit smoking, given the benefits of cessation and linking it with their current disease status by trained physician during their TB treatment in the first visit. Intervention 3: Smoker Control Groups: smoker patients with pulmonary tuberculosis which are under Tb Treatment and age and sex of them are matched with intervention group. They do not receive any intervention. Intervention 4: Non Smoker Control Groups: Non smoker patients with pulmonary tuberculosis which are under Tb Treatment and age and sex of them are matched with intervention group. They do not receive any intervention.