<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT2013072814190N1</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2013-08-21</date_registration>
      <primary_sponsor>Ahwaz Jundishapur University of Medical Sciences, Vice Chancellor for Research and technology</primary_sponsor>
      <public_title>Effect of Platelet-rich plasma treatment of male pattern baldness</public_title>
      <acronym></acronym>
      <scientific_title>Clinical evaluation of platelet- rich plasma effect on androgenic alopecia in men aged 25-45 years</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2013-02-19</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>19</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/13834</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment.</study_design>
      <phase>N/A</phase>
      <hc_freetext>Androgenetic Alopecia.</hc_freetext>
      <i_freetext>at the first, the Site was sterilized with alcohol,Using a 19-gauge needle, 10 ml of blood was collected in sterile conditions.afterwards,The sample was inserted in a disposable PRP kit.And Was shaken to mix the blood with the anticoagulant. Then placed in a centrifuge machine,Santryfyvzhshd speed of 3000 rpm for 6 minutes.When the plasma was separated from blood cells.The second time was centrifuged at a speed of 3300 rpm for 3 min.Thus, the plasma concentration of platelets (PRP) was obtained.&#13;
Compared with the patient's blood platelet count was more than 5 times in the sample. Finally,Calcium gluconate was added to the PRP, And creates favorable conditions for injection.PRP was prepared by the Department of Dermatology, Imam Khomeini Hospital, Ahwaz.For each patient, two regions with the lowest density of scalp hair have been selected.the area of each zone was 2.5 cm to 2.5 cm, And were 2.5 cm apart from each other and the extent of this area was identified by a tattoo.Injections are performed between the dermis and subcutaneous..</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan></results_IPD_plan>
      <results_IPD_description></results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Dr Sadegh shahryari</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Esfand avenue, Golestan bulvard ,Ahwaz Jundishapur University of Medical Sciences</address>
        <city>Ahwaz</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip></zip>
        <telephone>+98 61 1222 2114</telephone>
        <email>Sadegh_shahryari@yahoo.com</email>
        <affiliation>Ahwaz Jundishapur University of Medical Sciences</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Dr Mohamad Ali Mapar</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Esfand avenue, Golestan bulvard ,Ahwaz Jundishapur University of Medical Sciences</address>
        <city>Ahwaz</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>6193673166</zip>
        <telephone>+98 61 1222 2114</telephone>
        <email>Mapar@ajums.ac.ir</email>
        <affiliation>Ahwaz Jundishapur University of Medical Sciences</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Inclusion criteria: androgenetic alopecia according to the following scales: men: Hamilton/Norwood Scale: grades Va- VII and possibility of follow-up during the study.&#13;
Exclusion criteria:active inflammation or infection in the intervention area; presence of active systemic infections; background of cancerous or precancerous lesions; suffering from any serious blood disorders; to have undergone treatments for alopecia in the previous 6 months; previous hair implants; intake of drugs that affect hair loss; be undergoing immunosuppressive therapy and/or anticoagulants.</inclusion_criteria>
      <agemin>25 years</agemin>
      <agemax>45 years</agemax>
      <gender>Male</gender>
      <exclusion_criteria></exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code>L64.9</hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword>Androgenic alopecia, unspecified</hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Treatment - Drugs</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>at the first, the Site was sterilized with alcohol,Using a 19-gauge needle, 10 ml of blood was collected in sterile conditions.afterwards,The sample was inserted in a disposable PRP kit.And Was shaken to mix the blood with the anticoagulant. Then placed in a centrifuge machine,Santryfyvzhshd speed of 3000 rpm for 6 minutes.When the plasma was separated from blood cells.The second time was centrifuged at a speed of 3300 rpm for 3 min.Thus, the plasma concentration of platelets (PRP) was obtained.&#13;
Compared with the patient's blood platelet count was more than 5 times in the sample. Finally,Calcium gluconate was added to the PRP, And creates favorable conditions for injection.PRP was prepared by the Department of Dermatology, Imam Khomeini Hospital, Ahwaz.For each patient, two regions with the lowest density of scalp hair have been selected.the area of each zone was 2.5 cm to 2.5 cm, And were 2.5 cm apart from each other and the extent of this area was identified by a tattoo.Injections are performed between the dermis and subcutaneous.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Change from baseline in Hair density. Timepoint: 6 month. Method of measurement: Hair density (number of hairs per cm2) will be measured for each case.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome>Infection. Timepoint: 1 weak after Injection. Method of measurement: Clinical.</sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Ahwaz Jundishapur University of Medical Sciences, Vice Chancellor for Research and technology</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2013-08-06</approval_date>
        <contact_name>Ahwaz Ethic Committee of Jundishapur University of Medical Sciences</contact_name>
        <contact_address>Esfand avenue, Golestan bulvard ,Ahwaz Jundishapur University of Medical Sciences Ahwaz  Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
