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IRCT2013073014218N1 IRCT 2013-09-20 Tehran University of Medical Sciences the effectiveness of simultaneous use of analgesic drugs for pain control Comparison the effects of intra-articular sole ropivacaine and combined ketorolac and ropivacain for pain control after knee arthroscopy surgeries in patients referred to Rasul and Firuzgar Hospitals between 2012-2013 years 2013-08-23 anticipated 40 Complete https://irct.ir/trial/13863 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: it does not have. N/A pain control after arthroscopy surgery. Intervention 1: In Control group 150 mg of ropivacain soluted in salin 0.9% will be infused inta-articularly by arthroscope at the end of arthroscopy surgery. Intervention 2: In treatment group combination of 30 mg ketorolacand 150 mg ropivacain soluted in salin 0.9% will be infused inta-articularly by arthroscope at the end of arthroscopy surgery.
public Mehdi Masoomshahi
Rasul Akram Hospital, Anesthesiology group
Tehran Iran (Islamic Republic of) +98 21 4416 6270 m-masoomshahi@razi.tums.ac.ir Tehran University of Medical Sciences scientific Dr. Faranak Rokhtabnak
Firuzgar Hospital, Anesthesiology group
Tehran Iran (Islamic Republic of) +98 21 8894 2661 rkhtbnk@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Intrance criteria: to be pleased with participating in this study, the ages between 15 to 60 years old, to have knee arthroscopy surgery under general anesthesia Exit criteria: the history of using analgesics 24 hours before surgery, the history of bleeding or coagulation problems during the last month before surgery, renal and liver failure, severe cardiopulmonary, coagulopathy, morbid obesity (BMI<30 kg/m2), the history of nausea and vomiting after surgery, the history of migraine, the history of problems incidence during and after surgery, incidence of problems 24 hours after surgery which need the interference, known allergy, sensivity and contraindication about the use of opioid and non-opioid analgesics, pregnancy and lactation, the history of drug and alcohol abuse, being not to satisfied for participating in this study 15 years 60 years Both Z09.0 - Y4 Z09.0:Follow-up examination after surgery for other conditionsŲŒY45.9: Analgesic, antipyretic and anti-inflammatory drug, unspecified Treatment - Drugs Treatment - Drugs In Control group 150 mg of ropivacain soluted in salin 0.9% will be infused inta-articularly by arthroscope at the end of arthroscopy surgery In treatment group combination of 30 mg ketorolacand 150 mg ropivacain soluted in salin 0.9% will be infused inta-articularly by arthroscope at the end of arthroscopy surgery Pain. Timepoint: after entrance to recovery room and 2, 4, 8, 12, 18, 24 hours after surgery. Method of measurement: according to VAS (Visual Analog Scale), 0:no pain, 1-3:slight, 4-7:moderate, 8-10:sever. Nausea, vomiting and sedation. Timepoint: after entrance to recovery room and 2, 4, 8, 12, 18, 24 hours after surgery. Method of measurement: according to nausea and vomiting scale by patient's explaining about his/her symptoms (no nausea and vomiting/nausea/one to two order of nausea and vomiting/ nausea and vomiting more than two orders) - according to Ramsay sedation scale (1:Anxious or restless or both, 2:Cooperative, orientated and tranquil, 3:Responding to commands, 4:Brisk response to stimulus, 5:Sluggish response to stimulus, 6:No response to stimulus). Tehran University of Medical Sciences Approved 2013-08-21 Tehran University of Medical Sciences 6th floor, Central Organization of Tehran University of Medical Sciences, corner of Ghods St., Keshavarz Ave. Tehran Iran (Islamic Republic of)