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IRCT2014050514297N2 IRCT 2014-06-01 Vice chancellor for research, Tehran University of Medical Sciences Comparison of analgesic effects of Morphine and Indomethacin suppositories in patients with clinical diagnosis of renal colic Comparison of analgesic effects of Morphine and Indomethacin suppositories in patients with clinical diagnosis of renal colic referred to emergency wards of Shariati and Imam Khomeini hospitals 2014-03-21 anticipated 158 Complete https://irct.ir/trial/13916 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Renal Colic. Intervention 1: In the first intervention group, 100 mg Indomethacin suppository (the standard treatment for renal colic) is administered. Intervention 2: In the other group 10 mg morphine suppository is administered.
public Forough Zamanian
Keshavarz Blvd, Imam Khomeini Hospital
Tehran Iran (Islamic Republic of) +98 21 6690 4848 dr.foroughzamanian@gmail.com Imam Khomeini Hospital scientific Seyed Mojtaba Aghili
Imam Khomeini Hospital, Keshavarz Blvd
Tehran Iran (Islamic Republic of) +98 21 6690 4848 m-aghili@tums.ac.ir Imam Khomeini Hospital Iran (Islamic Republic of) Inclusion criteria: Patients between 18-85 years old with clinical diagnosis of renal colic referred to emergency ward; Consent to participate in the trial Exclusion criteria: Patient's refusal for entering the study; Pregnancy; Substance abuse; Taking analgesics 4 hours before referral; Past history of drug reaction to morphine or NSAIDs; Refuse to take rectal analgesic drug; Diarreha; Past history of chronic liver or kidney disease, COPD, Hypercapnea, Mild or severasthma, Sleep apnea syndorme, History of ileus, paralytic, Hypotension, IBD, Chronic Pancreatitis, Chronic bile duct dysfunction, Confusion, Severe anemia,Hipnotic drugs and phenothiazine, Adrenocortical dysfunction, Untreated hypothyroidism, Hypovolemia; Breast feeding; Chronic consumption of NSAIDs; Peritonitis 18 years 75 years Both N23 Unspecified renal colic Treatment - Drugs Treatment - Drugs In the first intervention group, 100 mg Indomethacin suppository (the standard treatment for renal colic) is administered. In the other group 10 mg morphine suppository is administered The analgesic effect of drugs. Timepoint: Immediately before, 20, 40, 60 and 90 minutes after drugs administration. Method of measurement: Pain scores (VAS). Vital sign changes. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Clinical examination. Nausea and vomiting. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Questionnaire. Drowsiness. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Questionnaire. Dry mouth. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Questionnaire. Allergy. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Clinical examination and Questionnaire. Vice chancellor for research, Tehran University of Medical Sciences Approved 2014-03-12 Ethics Committee of Tehran University of Medical Sciences Sixth Floor, Central Organization for University, Ghods St., Keshavarz's Blvd Tehran Iran (Islamic Republic of)