IRCT2013080814305N1 IRCT 2014-02-12 Mofid research excellence center Investigating the effect of oral desensitization in patients with acute alergy to cow milk based on Prik skin test Investigating the effect of oral desensitization in patients with acute alergy to cow milk based on Prik skin test 2013-05-01 anticipated 18 Complete https://irct.ir/trial/13921 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A cow's Milk allergy. Fifteen children over 3 year with history of anaphylaxis to cow’s milk, positive skin prick test ( SPT), and positive oral food challenge were recruited. Skin prick test with Milk extract, full dilution and different dilutions of milk, depends on patient’s reaction was performed for all the patients. The dilution of milk which induced 3-5 mm of wheal was selected as a stating dilution. Then it started form 2 drop of the dilution and increased according the protocol. The dose was increased weekly to achieve an intake of 120 mL in approximately 4 months. All doses were administered under medical supervision in a clinical setting. After receiving the dose, children were carefully assessed for positive reactions. In the cases of anaphylaxis the dose returned to the last tolerated dose for one week, then it was increased slower.