IRCT20130826014477N5 IRCT 2018-08-01 Mashhad University of Medical Sciences Comparison between the effectiveness of Crocus sativus and Crocin in the treatment of patients with major postpartum depression under common medical care. Investigation into the effectiveness of Crocus savitus and its active ingredient Crocin as a complementary approach in the treatment of patients with major postpartum depression receiving treatment, using triple blind random clinical trial controlled with placebo, plus assessment of the change in patients' Beck II score. 2018-08-06 anticipated 45 Complete https://irct.ir/trial/14102 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple, individual, unstratified randomization using randomization website's random number list and sealed envelope, Blinding description: After all the patients are diagnosed as suffering from postpartum depression by a psychiatrist, they are divided randomly into three groups by an academic individual with knowledge of scientific methods not taking part in the investigation, and their sealed envelope of medications for a period of two weeks and Beck II questionnaire are distributed among the patients by another individual other than the investigator, clinical health care provider and outcome analyst, then the collected data is handed to the investigator. 3 major postpartum depression. Intervention 1: Control group: Using placebo alongside the patient's main drug regimen. Intervention 2: Second intervention group: Tablets containing five mg Crocin (prepared in the Pharmacy faculty of Mashhad Medical University) taken orally twice a day for three months. Intervention 3: First intervention group: Tablets containing fifteen mg saffron (prepared in the Pharmacy faculty of Mashhad Medical University using Mashhad Saharkhiz company's saffron) taken orally twice a day for three months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is there is no more information.