IRCT2013082714489N1 IRCT 2014-04-07 Vice chancellor for research, Mashhad university of medical sciences Effect of fibrinogen on bleeding after cardiac surgery Studying effect of tranexamic acid plus fibrinogen on mediastinal bleeding in cardiac patients after open heart surgery 2013-11-22 anticipated 80 Complete https://irct.ir/trial/14116 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: The subjects are divided into control and intervention groups according to random number table. N/A Condition 1: Ischemic heart diseases. Condition 2: Nonrheumatic mitral valve disorders. Condition 3: Nonrheumatic aortic valve disorders. Condition 4: Nonrheumatic tricuspid valve disorders. Condition 5: Pulmonary valve disorders. Condition 6: Rheumatic heart diseases. Intervention 1: The subjects in the intervention group are injected with 15mg/kg tranexamic acid plus 2 g(grams) fibrinogen (Haemocomplettan as the generic name). Afterwards, the length of stay in the ICU, mediastinal bleeding, use of blood products, intubation time in ICU, discharge conditions and mortality are registered for each subject. These drugs are intravenously injected in one session, immediately after mediastinal bleeding of more than 200 cc/hr. The last stage in non-responder patients is re-exploration. Intervention 2: The second group consists of control subjects who receive 15 mg/kg tranexamic acid and routine care (including blood pressure control and use of blood products according to the paraclinical findings). The last stage in non-responder patients is re-exploration.