IRCT2013092914809N1 IRCT 2013-11-30 Vice Chancellor for Research and Technology, Hamedan University of Medical Science Effects of omega-3 supplements on prophylaxis of pediatric migraine Clinical trial to comparison the effect of omega-3 supplements and placebo on pediatric migraine prophylaxis in children treated with valproate sodium 2013-08-23 anticipated 24 Complete https://irct.ir/trial/14311 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: Placebo capsules with the same color, package, and shape as omega-3 capsules are produced by Zahravi Pharmaceutical Company. Patients are considered in one of two groups, A or B, with simple random sampling method and the code will be assigned to each of them. The patient and physician are unaware of the contents of the medical groups. The patients will be treated by the physician and they will be followed for at least 3 months. The frequency and severity of headache will be registered. At the end of treatment and after the registration of patient information, codes will be unveiled. 2 migraine. Intervention 1: Twenty mg/kg/day valproate sodium daily in 2 divided doses with one omega-3 capsule contain of 1 gr fish oil, Produced by Zahravi Pharmaceutical Company, for 3 months (intervention). Intervention 2: Twenty mg/kg/day valproate sodium daily in 2 divided doses with one placebo capsule (as the same color, package, and shape as omega-3 capsule without any active ingredient, Produced by Zahravi Pharmaceutical Company) for 3 months (control).