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IRCT2013100614915N1 IRCT 2014-10-11 Guilan University of Medical Sciences Effect of Centella asiatica on burning treatment Effects of topical ointment of Centella asiatica on partial thickness burning (A randomized clinical trial) 2014-10-23 anticipated 60 Complete https://irct.ir/trial/14375 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Partial thickness burning. Intervention 1: Intervention group: using topical solution derived from Centella asiatica. Intervention 2: Control group: treatment with Silver Sulfadiazine 1%.
public Amin Saeidinia
Medical faculty, Guilan University, 10th kilometer Tehran road, Rasht, Guilan, Iran
Rasht Iran (Islamic Republic of) +98 13 1669 0099 a.saeidynia@yahoo.com Guilan University of Medical Sciences scientific Dr. Javad Golchai; Dr. Ardalan Pasdaran
Razi hospital, Sardare Jangal Street, Rasht, Guilan, Iran/ Pharmacy faculty, Guilan University of Medical Sciences complex, Saravan-Fouman street, end of Lakan road, Rasht, Guilan, Iran
Rasht Iran (Islamic Republic of) +98 13 1555 0028 amin.saeidynia@gmail.com; ardalan.pasdar@gmail.com Guilan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: every partial thickness burning with less than 10% involved body and being in limbs; time of burning less than 48 hours; No other injury except of burning lesion and have general health body; age between 14 to 60 years Exclusion criteria: Existence of every cerebro-vascular diseases; cardiovascular diseases; endocrine diseases; liver diseases; renal diseases; history of abuse in alcohol or drugs; using antibiotic (oral or parenteral) at the same time; steroid or other immunosuppressive drug; burning due to lightning arresting; electrical instruments ; local burning of hand 14 years 60 years Both T20-T25 Burn of first degree of shoulder and upper limb, except wrist and hand Treatment - Drugs Treatment - Drugs Intervention group: using topical solution derived from Centella asiatica Control group: treatment with Silver Sulfadiazine 1% Subjective symptoms. Timepoint: Day 2,7 and 14 after initiating treatment. Method of measurement: It will be scored by below symptoms: dryness: 1=yes, 0=no; itching: 1=yes, 0=no; irritation: 1=yes, 0=no. Objective symptoms. Timepoint: Day 2,7 and 14 after initiating treatment. Method of measurement: It will be scored by below symptoms: Flexibility: 0=no, soft=1, yielding=2, stiff=3, sticky=4; Height: normal=0, 1-2mm=1, 3-4mm= 2, 5-6mm=3, >6mm=4; Vasculature: normal=0, pinky=1, red= 2, amethystine=3; Pigmentation: normal=0, mild=1, moderate=2, severe=3/ 0-4= lack of objective symptoms, 4-8= mild, 8-12= moderate, 12-14= severe. Surface of burning. Timepoint: Day 2,7 and 14 after initiating treatment. Method of measurement: By evaluation of morphometric features with image analyzer software. Severity of pain. Timepoint: Day 2,7 and 14 after initiating treatment. Method of measurement: By using Visual Analogue Score (VAS). Added at 2015-10-02: re-epithelialization. Timepoint: Added at 2015-10-02: from day o to complete of re-epithelialization. Method of measurement: Added at 2015-10-02: examination and observation with surgeon and sub-specialist of burning. Added at 2015-10-02: Complete Healing. Timepoint: Added at 2015-10-02: from day o to complete of complete healing of scar. Method of measurement: Added at 2015-10-02: examination and observation with surgeon and sub-specialist of burning. Guilan University of Medical Sciences Approved 2013-12-07 Research assistance of Guilan University of Medical Sciences- Ethics Comitee Research assistance of Guilan University of Medical Sciences, top of Iran radiator building, end of flying bridge, Imam Khomeini boulevard, Rasht, Iran Rasht Iran (Islamic Republic of)