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IRCT2016030515408N2 IRCT 2016-03-29 School of Traditional Medicine, Traditional Medicine and Materia Medica Research Center, Shahid Be A clinical trial evaluating of effect of Descurainia sophia (L.) on clinical symptoms of adult patients with functional constipation A clinical trial evaluating of effect of Descurainia sophia (L.) on clinical symptoms of adult patients with functional constipation 2014-12-21 anticipated 35 Complete https://irct.ir/trial/14668 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Relationship of Descurainia sophia L. with functional constipation in adults. Intervention: A spoonful of dry seeds of Descurainia sophia L. and a spoonful of sugar in a cup of boiling water are mixed and taken at fasting once a day. If the properties of defecation do not satisfy the patient , he is allowed to increase the dose of drug every three days to a maximum of 6 teaspoons / day..
public Dr. Anahita Ghourchian
No.8 Shams Alley, Opposite Sttree Tavanir, Vali Asr Street
Tehran Iran (Islamic Republic of) 1516745811 +98 21 8877 3525 dr.anahitaghourchian@sbmu.ac.ir ; anahitaghourchian@gmail.com School of Traditional Medicine, Traditional Medicine and Materia Medica Research Center, Shahid Behe scientific Dr.Rasool Choopani
No.8 Shams Alley, opposite St tavanir, Vali Asr Street
Tehran Iran (Islamic Republic of) 1516745811 +98 21 8877 3525 rchoopani@sbmu.ac.ir ; rchoopani@yahoo.com School of Traditional Medicine, Traditional Medicine and Materia Medica Research Center, Shahid Behe Iran (Islamic Republic of) Inclusion criteria: Age: 70-20 years at the time of screening; Ability to participate in the study and there is no obvious behavioral disorders, speech and language diaeres; No major abdominal surgery; Lack of self and family history of thyroid disease; Colon cancer screening in people over 50 years; Lack of warning signs (rectal bleeding and weight loss and anemia); No underlying disease affecting constipation (Parkinson, Multiple sclerosis, stroke, hypothyroidism, cancer); Lack of pregnancy or lactation; Speaking ins; Avoiding the use of antibiotics in the past 5 weeks; Not taking medications causing constipation; No addiction; Complete the consent form; Having normal routine tests, including complete blood count, fecal occult blood test, alkaline phosphatase and TSH test, liver enzymes and Cr; No previous sensitivities to herbal medicines; Absence of severe cardiovascular disease, especially functional class 3 & 4 of chronic heart failure; Lack of proven malignancy; Absence of liver disease (esophageal varices and bleeding, encephalopathy, ascites); Absence of symptomatic gallstone disease (in history); Absence of severe kidney disease (creatinine more than 3 mg / dl); Having the criteria for functional constipation ROMIII. Main exclusion criteria: Lack of durability of the above conditions; Unwillingness to continue participation in the study; Drug side effects or other threatening events. 20 years 70 years Both Treatment - Drugs Intervention: A spoonful of dry seeds of Descurainia sophia L. and a spoonful of sugar in a cup of boiling water are mixed and taken at fasting once a day. If the properties of defecation do not satisfy the patient , he is allowed to increase the dose of drug every three days to a maximum of 6 teaspoons / day. The proportion of patients reaching three or more spontanouse complete bowel movement/week. Timepoint: At the begining, before the intervention and 4 weeks after, at the end of study. Method of measurement: By interviews with patients and asking them. The number of laxatives used. Timepoint: At the begining, before the intervention and 4 weeks after, at the end of study. Method of measurement: By interviews with the patients and asking them. The score of a check list of Patient Assessment of Constipation Symptoms (PAC-SYM) items. Timepoint: At the begining, before the intervention and 4 weeks after, at the end of study. Method of measurement: By interviews with the patients and asking them. The type of stool according to Bristol chart. Timepoint: At the begining, before the intervention and 4 weeks after, at the end of study. Method of measurement: By interviews with the patients and asking them. School of Traditional Medicine, Traditional Medicine and Materia Medica Research Center, Shahid Be Approved 2014-05-04 Office of Research Affairs, Deputy of Research and Technology, Shahid Beheshti University of Medical Sixth Floor, College Staff Building Number Two, Shahid Beheshti University of Medical Sciences, next to Taleghani Hospital, Parvaneh st., Yemen st., Shahid Chamran Highway Tehran Iran (Islamic Republic of)