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IRCT2014082515510N2 IRCT 2014-10-04 Vice Chancellor for research of Mazandaran University of Medical Sciences Proton pump inhibitors, oral and injectable, in preventing peptic ulcer re-bleeding Comparison of proton pump inhibitors, oral and injectable, in preventing rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. 2014-09-23 anticipated 260 Complete https://irct.ir/trial/14760 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: NO. N/A gastroduodenal ulcer. Intervention 1: " intervention group: We will give pantoprazole tablet 40 mg every 12 hours for 72 hours and then will continue with same dose for 4 weeks. Intervention 2: "Control group: We will give IV pantoprazole 40 mg as stat dose and then 8 mgr per hours for 72 hours .we will continue pantoprazole tablet 40 mgr twice daily for 4 weeks.
public Seyed Mohammad Valizadeh Toosi
Department of Gastroenterology, Imam Khomeni Hospital, Amire Mazandarani Street
Sari Iran (Islamic Republic of) 48166-33131 +98 11 3337 7176 sm.valizadehtoosi@mazums.ac.ir seyedmohammadv@yahoo.com Inflammatory Diseases of Upper Gastrointestinal Tract Research Center scientific Seyed Mohammad Valizadeh Toosi
Inflammatory Diseases of Upper Gastrointestinal Tract Research Center, Department of Gastroenterology, Imam Khomeni Hospital, Amir Mazandarani Street
Sari Iran (Islamic Republic of) +98 11 3337 7176 sm.valizadehtoosi@mazums.ac.ir seyedmohammadv@yahoo.com Inflammatory Diseases of Upper Gastrointestinal Tract Research Center Iran (Islamic Republic of) Inclusion Criteria: Every person with upper gastrointestinal bleeding due to peptic ulcer, which is the new log endoscopic bleeding (bleeding ulcer in the jet, the vessel featured in the wound bed, the wound with mild persistent bleeding, and ulcers with adherent clots in bed ). Exclusion criteria: patients with upper GI bleeding with other causes, such as bleeding from esophageal or gastric varices or cancer and patients with clean base peptic ulcer without active bleeding. no limit no limit Both k27 Peptic ulcer, site unspecified Treatment - Drugs Treatment - Drugs " intervention group: We will give pantoprazole tablet 40 mg every 12 hours for 72 hours and then will continue with same dose for 4 weeks "Control group: We will give IV pantoprazole 40 mg as stat dose and then 8 mgr per hours for 72 hours .we will continue pantoprazole tablet 40 mgr twice daily for 4 weeks. Endoscopic evidence of bleeding from gastric or duodenal ulcer. Timepoint: ‌Before intervention, 72 hours an 4 weeks after intervention. Method of measurement: Endoscopy before intervention, check of blood pressureand hemoglobin 72 hours and 4 weeks after intervention. The number of units of blood required. Timepoint: 8 weeks after intervention. Method of measurement: Questionnaire. Need for surgery. Timepoint: Upto 4 weeks after intervention. Method of measurement: Questionnaire. Days of hospitalization. Timepoint: Upto 4 weeks after intervention. Method of measurement: Questionnaire. The need for re-endoscopy because of bleeding. Timepoint: Upto 4 weeks after intervention. Method of measurement: Questionnaire. Vice Chancellor for research of Mazandaran University of Medical Sciences Approved 2014-09-06 Ethics committee of Mazandaran University Of Medical sciences Moallem Squre Sari Iran (Islamic Republic of)