IRCT2013121715655N2 IRCT 2014-06-27 Tehran University Of Medical Sciences Effects of Methotrexate on oral lichen planus Assesment of the efficacy of methotrexate on patients with oral lichen planus 2014-01-21 anticipated 15 Complete https://irct.ir/trial/14867 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A lichen planus. In this study, in the first week, 7.5 mg methotraxate per week (three tablets, 2.5 milligrams) plus 1mg folic acid per day will be administered and from the next week, 15 mg per week plus 1mg folic acid per day in condition of tolerance will be administered. Treatment duration is 12 weeks. In each visit, each patient will be evaluated for leukopenia, anemia, thrombocytopenia, liver function and kidney function..

public Zahra Shafiee

Razi Hospital, Vahdat Eslami st, Vahdat Eslami square, Hafez st, Tehran, Iran

Tehran Iran (Islamic Republic of) +98 21 5560 9951 lajevardi@tums.ac.ir; ze_1367@yahoo.com Razi Hospital scientific Vahide Lajevardi

Razi Hospital, Vahdat Eslami st, Vahdat Eslami Square, Hafez st, Tehran, Iran

Tehran Iran (Islamic Republic of) +98 21 5560 9951 lajevardi@tums.ac.ir; vahide_lajevardi@yahoo.com Razi Hospital Iran (Islamic Republic of) Inclusion criteria: patients with oral lichen planus, diagnosed by clinical and pathological criteria, who did not respond to topical therapy. Exclusion criteria: Pregnancy and breast feeding; cancer; severe and frequent infections; Hereditary or acquired immunodeficiency; leukopenia; anemia; thrombocytopenia; hepatic dysfunction; Stomach ulcers; dysplastic lesions in pathology; ulcerative colitis disease; side effects of methotraxate no limit no limit Both L43.8 Other lichen planus Treatment - Drugs In this study, in the first week, 7.5 mg methotraxate per week (three tablets, 2.5 milligrams) plus 1mg folic acid per day will be administered and from the next week, 15 mg per week plus 1mg folic acid per day in condition of tolerance will be administered. Treatment duration is 12 weeks. In each visit, each patient will be evaluated for leukopenia, anemia, thrombocytopenia, liver function and kidney function. The resolution of oral lesions. Timepoint: Before treatment and at two, four, eight and twelve weeks. Method of measurement: Thongprasom Scale. Pain reduction. Timepoint: Before treatment and at weeks two, four, eight and twelve. Method of measurement: VAS ( Visual Analog Scale) Pain was scored from zero to ten. The side effects of methotraxate. Timepoint: First, fourth, eighth and twelfth week. Method of measurement: Examination in each visit. The Size of lesions. Timepoint: First, fourth, eighth and twelfth week. Method of measurement: Transparent grid ( mm ). Duration of disease since diagnosis. Timepoint: Before treatment. Method of measurement: Interview. The type of lesion (ulcerative , reticular , atrophic). Timepoint: Before treatment. Method of measurement: previous records. The location of lesions (bucal , gingival , palatine). Timepoint: Before treatment. Method of measurement: previous records. Tehran University Of Medical Sciences Approved 2012-09-01 Research Ethics Committee at Tehran University of Medical Sciences Central Organization of Tehran University of Medical Sciences, Ghods st, Keshavarz blvd, Tehran, Iran Tehran Iran (Islamic Republic of)