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IRCT20131216015814N3 IRCT 2018-02-21 Qazvin University of Medical Sciences The effect of premedication on tooth anesthesia Efficacy of premedication with ibuprofen on the success of lower alveolar nerve block with lidocaine in comparison with infiltration of articaine in symptomatic irreversible pulpitis. 2017-11-22 anticipated 88 Complete https://irct.ir/trial/14972 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Factorial, Purpose: Treatment, Randomization description: From patients with symptomatic irreversible pulpitis referring to the Department of Endodontics, Faculty of Dentistry Qazvin, 88 patients will be randomly selected on the basis of win pepi software, Blinding description: None of the patients, the practitioner, and the statistician are aware of the contents of the capsules, and only the manufacturer of the drug is aware of the contents of the capsules. All capsules containing the drug or placebo have the same shape and color and size and have their own code. In Group 1 and 2 placebo capsules, and in groups 3 and 4, ibuprofen 400 mg capsules are given to the patients. 3 Irreversible pulpitis. Intervention 1: Intervention 1:Premedication with ibuprofen (400 mg) 30 minutes before anesthesia and infiltration of articaine 4% + epinephrine 1.100000. Intervention 2: Intervention 2: Premedication with placebo 30 minutes before anesthesia and infiltration of articaine 4% + epinephrine 1.100000. Intervention 3: Intervention group: Intervention 3: Premedication with ibuprofen (400 mg) 30 minutes before anesthesia and IANB anesthesia with lidocaine 2% + epinephrine 1.100000. Intervention 4: Intervention 4: Premedication with placebo 30 minutes before anesthesia and IANB anesthesia with lidocaine 2% + epinephrine 1.100000. Yes - There is a plan to make this available What will be shared: All the information of the participants When: Up to one year after the publication of the results To whom: Free access to data for all people Conditions: Data will be available for designing further studies and meta-analyzes Where to obtain: To communicate with Ramezani masoumeh Mobile number:09129490407 Email:M269_ramezani@yahoo.com How to obtain: Up to 2 weeks Comments:
public Shahrzad Jalali
Endodontic department, Dental School, University of Medical sciences, Bahonar Blvd.,Qazvin Town
Qazvin Iran (Islamic Republic of) 3414685537 +98 28 3335 3061 Jalali.shahrzad@gmail.com Qazvin Dental School scientific Shahrzad Jalali
Endodontic department, Dental School, Qazvin University of Medical Sciences, Bahonar Blvd.Qazvin town,
Qazvin Iran (Islamic Republic of) 3415759811 +98 28 3335 3061 Jalali.shahrzad@gmail.com Qazvin dental school Iran (Islamic Republic of) Patients with first or second mandibular molars requiring root canal treatment with the diagnosis of symptomatic irreversible pulpitis and a history of spontaneous pain. Patients who are completely healthy or have a mild systemic disease that is well controlled (ASA I, II) Patients who have the ability to fill out a questionnaire and a consent letter Patients over 18 years old 18 years 50 years Both Patients with heart pacemakers Asthma, coagulation disorders, immune deficiency, diabetes, hypertension, mental disorders pregnancy Sensitivity or contraindication for receiving lidocaine, articaine, epinephrine and NSAIDs The presence of open apex or calcification in the root of the Intended tooth The presence of extensive restoration or periodontal disease use of analgesic drugs 12 hours before treatment Treatment - Drugs Placebo Treatment - Drugs Placebo Intervention 1:Premedication with ibuprofen (400 mg) 30 minutes before anesthesia and infiltration of articaine 4% + epinephrine 1.100000 Intervention 2: Premedication with placebo 30 minutes before anesthesia and infiltration of articaine 4% + epinephrine 1.100000 Intervention group: Intervention 3: Premedication with ibuprofen (400 mg) 30 minutes before anesthesia and IANB anesthesia with lidocaine 2% + epinephrine 1.100000 Intervention 4: Premedication with placebo 30 minutes before anesthesia and IANB anesthesia with lidocaine 2% + epinephrine 1.100000 Pain during cavity preparation. Timepoint: Fifteen minutes after injection. Method of measurement: Visual analogue scale. Need for complementary injection. Timepoint: Fifteen minutes after block injection. Method of measurement: Complementary anesthetizing. Qazvin University of Medical Sciences Approved 2010-09-23 Ethics committee of Qazvin University of Medical Sciences Faculty of Dentistry Qazvin,Shahid Bahonar Blvd., Qazvin Qazvin Qazvin Iran (Islamic Republic of)