<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT20140223N115938</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2014-02-23</date_registration>
      <primary_sponsor>Shiraze University of Medical Sciences ،Researh</primary_sponsor>
      <public_title>Blood loss in Rhinoplasty surgery</public_title>
      <acronym></acronym>
      <scientific_title>A comparison of Remifentanil and Labetalol infusion on intraoperative bleeding during Rhinoplasty surgery</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2014-02-20</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>60</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/15047</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment.</study_design>
      <phase>N/A</phase>
      <hc_freetext>q00-q99.</hc_freetext>
      <i_freetext>Intervention 1: After being anesthetized patients before surgical incision a group of 30 patients  drug Labetalol  with dose /4-3 mg/ kg/hr beginning to the end of the operation with a 50 cc syringe infusion pump operation will start. Mean Arterial Pressure (MAP) is  in the range of 55-65 mm/Hg .In this area we have to see how  much bleeding. Intervention 2: After being anesthetized patients before surgical incision a group of 30 patients drug Remifentanil with dose /1-3 mic/kg/min beginning to the end of the operation with a 50cc syringe infusion pump operation will start. Mean Arterial Pressure( MAP) is in the range of 55-65 mm/Hg  .In the area we have to see how much bleeding.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan></results_IPD_plan>
      <results_IPD_description></results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Abdoreza Gholami</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Office of anesthsia ، Faghi hospital ، Zand Blvd</address>
        <city>Shiraz</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>00987117134844119</zip>
        <telephone>+98 71 1231 8072</telephone>
        <email>gholamireza1256@yahoo.com</email>
        <affiliation>Shiraz Universityof Medical Sciences</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Abdoreza Gholami</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Office of Anesthesia،  Faghi hospital ، Zand Blvd</address>
        <city>Shiraz</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>7134844119</zip>
        <telephone>+98 71 1231 8072</telephone>
        <email>www.gholami_a@internet.sums.ac.irwww.gholamireza1256@yahoo.com</email>
        <affiliation>shiraz University of Medical Sciences</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Inclusion:The patient with ASA 1-2 ;Men or Women between 18- 50 years; Disease without surgery Rhinoplasty;No patient had a history or physical exam of clotting problems; Blood pressure above then 100/70 mm/Hg ;Heart rate above then 40 mint;No history of Obstractive lung disease and Heart disease .&#13;
&#13;
Exclusion criteria: Patient with ASA above 2;Men or Women with  Age less then 18 years and  age above then 50 years; Repeat Rhinoplasty surgery ;Coagulation problem in history and physical exam;Blood pressure less then100/70mm/Hg;Heart rate less then 40 mint;History Obstractive lung disease and any Heart disease.</inclusion_criteria>
      <agemin>18 years</agemin>
      <agemax>50 years</agemax>
      <gender>Both</gender>
      <exclusion_criteria></exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code>q30-q34</hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword>q30/9 -Congenital Malformation of nose ، Unspecitied</hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Treatment - Drugs</i_code>
      <i_code>Treatment - Drugs</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>After being anesthetized patients before surgical incision a group of 30 patients  drug Labetalol  with dose /4-3 mg/ kg/hr beginning to the end of the operation with a 50 cc syringe infusion pump operation will start. Mean Arterial Pressure (MAP) is  in the range of 55-65 mm/Hg .In this area we have to see how  much bleeding.</i_keyword>
      <i_keyword>After being anesthetized patients before surgical incision a group of 30 patients drug Remifentanil with dose /1-3 mic/kg/min beginning to the end of the operation with a 50cc syringe infusion pump operation will start. Mean Arterial Pressure( MAP) is in the range of 55-65 mm/Hg  .In the area we have to see how much bleeding.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>The amount of intraoperative bleeding. Timepoint: The end of surgery. Method of measurement: Measurement of blood in the suction.</prim_outcome>
      <prim_outcome>Evaluate the quality of the surgical site by the Surgen. Timepoint: The end of surgery. Method of measurement: Evaluate with table Boezaart by Surgen.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome>Mean Artrial Pressure. Timepoint: During  the study every 15 minute. Method of measurement: Pressure Set-Blood Pressure  Monitoring.</sec_outcome>
      <sec_outcome>Heart Rate. Timepoint: During  the study every 15 minute. Method of measurement: Anesthesia Monitoring.</sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Shiraze University of Medical Sciences ،Researh</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2014-01-12</approval_date>
        <contact_name>Shiraz University of Medical Sciences، Research</contact_name>
        <contact_address>Research ، Central Building Danesgah،  Zand  Blvd Shiraz  Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
