IRCT2014052515975N1 IRCT 2014-06-17 Semnan University of Medical Sciences, Semnan, Iran Effects of acute stress on declarative memory reconsolidation across menstrual cycle Effects of acute stress on declarative memory reconsolidation across menstrual cycle in healthy women 2013-12-22 anticipated 56 Complete https://irct.ir/trial/15085 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Crossover, Purpose: Basic scienece. N/A Stress. Intervention 1: In stress condition, participants expose to the socially evaluated cold pressor test (SECPT). Subjects will ask to immerse their right hand up to and including the wrist into ice water (0-2 C). Subjects would be asking to remain immersed for 3 min, but tell that they are free to pull out at any time without penalty. During hand immersion they will videotaping, ask to look into the video camera and tell that these video recordings would be analyzed later for facial expression. The SECPT has been shown to elicit significant increases in cortisol and autonomic activity. In the control condition, individuals immerse their right hand up to and including the wrist for 3 min into warm water (35—37 ºC). They are not videotape. Intervention 2: Memory Task. Day1: Learning; On day 1, participants learn 30 pictures include ten positive pictures (such as Ice cream), ten negative pictures (example Injury) and ten neutral pictures(glass). Day2: Reactivation; On day 2, participants in reactivation group would be asked to remind the pictures they had learned on the previous day. In no reactivation group, participants reading newspaper. Immediately, they are challenging with Stress or Control. Day3: Retrieval and Recognition; On day 3, participants would be asked to write down the pictures they had learned on day 1. Cued recall will be assessed immediately after free recall. After 2 months, participants return for days 4, 5, and 6, during which the same procedures with the alternate condition (Stress or Control).