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IRCT2014010816136N1 IRCT 2014-05-18 Kashan University of Medical Sciences Effect of mitomycine C on DCR (Dacryosystorhinostomy) Effect of mitomycine C on DCR (Dacryosystorhinostomy) with endonasal endoscopic guidance in lacrimal duct stenosis referring to medical center affiliated to Kashan university of medical sciences 2014-05-22 anticipated 92 Complete https://irct.ir/trial/15192 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Stenosis of lacrimal passages. Intervention 1: During surgery sponge impregnated with 0.02 precent mitomycin C use in osteotomy site for five minutes and then Wash with 50 cc normal saline and clean with endonasal endoscopic guidance. Intervention 2: For control group Dacryosystorhinostomy under general anesthesia is routinely performed with placebo instead of Mitomycine C.
public Fatemeh Rangraz Jeddi
Kashan University of Medical Sciences, Ravand avenue
Kashan Iran (Islamic Republic of) +98 36 1555 0021 angrazejeddi_f@kaums.ac.ir Kashan University of Medical Sciences scientific Mehdi Shaeri
Kashan University of Medical Sciences, Ravand avenue
Kashan Iran (Islamic Republic of) +98 36 1555 0021 shaeri_m@kaums.ac.ir Kashan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: age between 35-65 years old and tearing along with (Recurrent acute dacryocystitis); increase in lacrimal minisc; have a reflux when the pressure on the lacrimal sac; confirmed the diagnosis of nasolacrimal lavage selected. Patient with history of tearing at birth, trauma to face and nose, nasal and sinus surgery, mucosal lacrimal sac, canalicole obstruction, coagulation disorders, hemophilia, other external nasal disease, lacrimal sac neoplasm, corneal ulcers or foreign body on cornea, abnormality in ponctum position are excluded from study. 35 years 65 years Both H04.5 Stenosis and insufficiency of lacrimal passages Treatment - Drugs Placebo During surgery sponge impregnated with 0.02 precent mitomycin C use in osteotomy site for five minutes and then Wash with 50 cc normal saline and clean with endonasal endoscopic guidance. For control group Dacryosystorhinostomy under general anesthesia is routinely performed with placebo instead of Mitomycine C Tearing. Timepoint: One week, one month, six months after surgery. Method of measurement: yes/no. Tearing reflex. Timepoint: One day, one week, one month and six months. Method of measurement: no/ purulent/ aqueous. Kashan University of Medical Sciences Approved 2013-08-13 Ethics Committee of Kashan University of Medical Sciences Kashan University of Medical Sciences, Ravand avenue Kashan Iran (Islamic Republic of)