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IRCT2014012616374N1 IRCT 2015-12-23 Vice chancellor for research, university of Social Welfare & Rehabilitation sciences The effect of bumetanide on schizophrenia patients Bumetanide The effect of bumetanide on positive , negative and cognitive symptoms of schizophrenic patients 2015-09-23 anticipated 20 Complete https://irct.ir/trial/15344 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A schizopherenia. Intervention 1: Control group: take placebo . tab per day . Oral during 3months. Intervention 2: Intervention group: take Bumetanide(Made in Belgium) as an adjuvant therapy - made in Belgium Tab , 1mg twice daily. Oral. During 2months.
public Dr. Mohammad Reza khodaie Ardakani
Razi Psychiatric Hospital ، shahre Rey، Tehran
Tehran Iran (Islamic Republic of) 1313913139 +98 21 3340 1604 kh.ardakani@uswr.ac.ir University of Social Welfare & Rehabilitation Sciences scientific Mohammad Reza khodaie Ardakani
Razi psychiatric Hospital ، shahre Rey، Tehran
Tehran Iran (Islamic Republic of) +98 21 3340 1604 kh.ardakani@uswr.ac.ir University of Social Welfare & Rehabilitation Sciences Iran (Islamic Republic of) inclusion criteria: (1) Diagnosis of schizophrenia at any subtype according to DSM-IV diagnosis an statistical manual of mental disorders, 4th edition (2) aged 20 to 70 years (3) disease duration for at least 3 years (4) had a total score of at least 70 on the positive and negative syndrome scale(PANSS) (5) had persistent negative or considerable cognitive symptoms, that are equivalent with at least 20 and 15 score on the negative and cognitive subscales of PANSS, respectively. Exclusion criteria were: patients with a (1) documented fluctuation in symptoms (2) uncontrollable significant conditions (3) As well as concurrent history of significant psychiatric (except schizophrenia), cardiovascular, renal, hepatic, convulsive disorders or substance abuse. 18 years 55 years Both f20 schizopherenia Treatment - Drugs Treatment - Drugs Control group: take placebo . tab per day . Oral during 3months Intervention group: take Bumetanide(Made in Belgium) as an adjuvant therapy - made in Belgium Tab , 1mg twice daily. Oral. During 2months Negative, positive and cognitive symptoms of schizopherenic patients. Timepoint: Before treatment and 1, 2 months after treatment and following one-month drug-free washout period. Method of measurement: PANSS and BPRS inquiries. Side effect. Timepoint: at assessment interviews; before treatment and 1,2 months after treatment and after one-month drug-free washout period. Method of measurement: AIMS test and clinical observation. Vice chancellor for research, university of Social Welfare & Rehabilitation sciences Approved 2014-02-01 Ethis committee ofuniversity of social welfare&rehabilitation sciences University of Social Welfare & Rehabilitation Sciences، Koodakyar street، Velenjac Tehran Iran (Islamic Republic of)