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IRCT2014041416466N3 IRCT 2014-06-27 Shahid Beheshti Universiy of Medical Sciences Management of orthodontic pain Comparative effect of Ketoprofen and Benzocaine chewing gums in reducing orthodontic pain 2013-09-23 anticipated 30 Complete https://irct.ir/trial/15399 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Prevention. N/A orthodontic pain. Intervention 1: ketoprofen(Keto) chewing gum was manufatured with 75mg ketoprufen in R& D department of Minoo industrial company under the consultant pharmacologist. The chewing gum consists of gumbase,sorbitol,Xylitol,malnitol,aspartam,A3sulfamK,ocaliptus essence.Ketoprufen was provided from Switzerland.Keto gum will be instructed immediately after each orthodontic intervention(considering wash-out time) for each of the 30 patients and will be continued every 8 hours till day 7. Intervention 2: Benzocain chewing gum (Benzo) chewing gum was manufatured with 20% benzocain in R& D department of Minoo industry company under the consultant pharmacologist. The chewing gum consists ofgumbase,sorbitol,Xylitol,malnitol,aspartam,A3sulfamK,ocaliptus essence.Benzo was provided from Switzerland.Benzo gum will be instructed immediately after each orthodontic intervention for each of the 30 patients ( providing wash-out time) and will be continued every 8 hours till day 7. Intervention 3: Placebo chewing gum chewing gum was manufatured in R& D department of Minoo industry company under the consultant pharmacologist. The chewing gum consists ofgumbase,sorbitol,Xylitol,malnitol,aspartam,A3sulfamK,ocaliptus essence .Placeboo gum will be used immediately after each orthodontic intervention for each of the 30 patients(considering wash-out time) and will be continued every 8 hours till day 7.
public Sara Yousefinia
Shahid Beheshti University of Medical Sciences, Daneshjoo blvd, Chamran Exp.way
Tehran Iran (Islamic Republic of) 19834 +98 21 2990 2304 yousefiniasara@gmail.com Shahid Beheshti Universiy of Medical Sciences scientific Ladan Eslamian
Shahid Beheshti University of Medical Sciences, Daneshjoo blvd, Chamran Exp.way
Tehran Iran (Islamic Republic of) 19834 +98 21 8878 2440 leslamian@gmail.com Shahid Beheshti Universiy of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: participants, in good general health without any reported systematic diseases; no concurrent use of analgesics and anti-inflammatory drugs; feel pain more than 50 according to VAS after previous appointment; caries-free dentition with healthy periodontium and without any endodontic problems in the posterior part of the mouth; crowding between 6-8mm and stage of TX in levelling and alignment stage. Patients will be excluded from the study if they used analgesics and anti-inflammatory drugs during the study, did not complete the questionnaire, did not use or improperly used benzocaine or ketoprofen chewing gums. 15 years 25 years Both XXI Factors influencing health status and contact with health services Treatment - Drugs Treatment - Drugs Placebo ketoprofen(Keto) chewing gum was manufatured with 75mg ketoprufen in R& D department of Minoo industrial company under the consultant pharmacologist. The chewing gum consists of gumbase,sorbitol,Xylitol,malnitol,aspartam,A3sulfamK,ocaliptus essence.Ketoprufen was provided from Switzerland.Keto gum will be instructed immediately after each orthodontic intervention(considering wash-out time) for each of the 30 patients and will be continued every 8 hours till day 7. Benzocain chewing gum (Benzo) chewing gum was manufatured with 20% benzocain in R& D department of Minoo industry company under the consultant pharmacologist. The chewing gum consists ofgumbase,sorbitol,Xylitol,malnitol,aspartam,A3sulfamK,ocaliptus essence.Benzo was provided from Switzerland.Benzo gum will be instructed immediately after each orthodontic intervention for each of the 30 patients ( providing wash-out time) and will be continued every 8 hours till day 7. Placebo chewing gum chewing gum was manufatured in R& D department of Minoo industry company under the consultant pharmacologist. The chewing gum consists ofgumbase,sorbitol,Xylitol,malnitol,aspartam,A3sulfamK,ocaliptus essence .Placeboo gum will be used immediately after each orthodontic intervention for each of the 30 patients(considering wash-out time) and will be continued every 8 hours till day 7. Pain. Timepoint: 2 h, 6h, 24h, day2(10am and 6 pm), day3(10am and 6 pm) and day7(10 am and 6 pm). Method of measurement: 100 scores visual analogue scale. Shahid Beheshti Universiy of Medical Sciences Approved 2014-01-05 Shahid Beheshti University of Medical Sciences Shahid Beheshti University of Medical Sciences, Daneshjoo blvd, Chamran Exp.way Tehran Iran (Islamic Republic of)