IRCT2016010716466N4 IRCT 2016-03-07 Shahid Beheshti University of Medical Science, School of Dentistry, Orthodontic department prevention of orthodontic pain The comparison of the effect of 5% naproxen gel and the placebo gel on reduction of fixed orthodontic pain after elastic separator placement; a randomized clinical trial study 2016-01-20 anticipated 30 Complete https://irct.ir/trial/15400 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Prevention. 2-3 The effect of 5% naproxen gel on orthodontic pain reduction. Intervention 1: Naproxen gel, 5%, every 8 hours up to 3 days. Intervention 2: Placebo gel, every 8 hours, up to 3 days.

public Azade Kianipour

No. 3, Golestan Avenue, North Golestan St., Karmandan town, Kermanshah, Iran

Kermanshah Iran (Islamic Republic of) کرمانشاه +98 83 3423 0357 azadehkianipour@ymail.com Shahid Beheshti University of Medical Science, School of Dentistry scientific Ladan Eslamian

The Orthodontic department, the third floor, School Of Dentistry, Shahid Beheshti University of Medical Science, Evin, Shahid Chamran highway, Tehran, Iran

Tehran Iran (Islamic Republic of) +98 21 2990 2304 leslamian@gmail.com; ladaneslamian@yahoo.com Shahid Beheshti University of Medical Science, School of Dentistry, Orthodontic department Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: Men and female with 14-20 year old of ages; patients have no pain in teeth and gingiva at the beginning of study.; presence of tight contact between first molar with adjacent teeth and clinician needs to place bilateral elastic separators for molar banding and there is no space between the teeth in the jaw.; Patients are without posterior open bite and the first molars should have antagonist teeth in the opposite jaw.; patients present pain after separator placement. Exclusion criteria: Patients who do not use naproxen gel and placebo gel will be omitted from the study.; patients who do not complete all parts of the questionnaire forms will be omitted from the study.; patients who use other analgesic drugs during the study will be omitted.; removal of any of separators 14 years 20 years Both Prevention Placebo Naproxen gel, 5%, every 8 hours up to 3 days Placebo gel, every 8 hours, up to 3 days Pain after orthodontic separator placement. Timepoint: 2hours after first use, 6 hours after first use, 10A.M and 6 P.M on days 2,3 and 7 after separator placement. Method of measurement: Visual Analogue Scale. Shahid Beheshti University of Medical Science, School of Dentistry Shahid Beheshti University of Medical Science, School of Dentistry, Orthodontic department Shahid Beheshti University of Medical Science, School of Dentistry Approved 2014-03-08 Shahid Beheshti University of Medical Science, School Of Dentistry The Research center, the forth floor, School Of Dentistry, Shahid Beheshti University of Medical Science, Evin, Shahid Chamran highway, Tehran, Iran Tehran Iran (Islamic Republic of)