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IRCT2014020816524N1 IRCT 2014-11-30 Vice Chancellor for Research, Shiraz University of Medical Sciences Effect of Alfentanil and Remifentanil on QT Interval Comparison of the Effect of Alfentanil and Remifentanil on QT Interval in Septoplasty with Local Epinephrine 2014-05-22 anticipated 80 Complete https://irct.ir/trial/15448 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2 QT Prolongation. In intervention group we use alfentanil 20-25 microgram/kg in induction and with rate of 0.5-2 microgram/kg/min in maintenance .In control group remifentanil is use with dose of 1-2 microgram/kg in induction and infused with rate of 0.2-0.25 microgram/kg/min in maintenance of anesthesia..
public Fatemeh Toobaei
Anesthesiology Office, Shahid Faghihi HospitaL, Zand Street
Shiraz Iran (Islamic Republic of) +98 71 3233 7636 toobaeif@sums.ac.ir Shiraz University of Medical Sciences scientific Mansoor Masjedi
Anesthesiology office, Namazi Hospital
Shiraz Iran (Islamic Republic of) +98 713647427000 masjedi@sums.ac.ir Shiraz University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients with physical status class I -II, based on the classification of the American Society of Anesthesiologists (ASA) and the age up to50 years undergoing septoplasty. Exclusion criteria: the use of any effective drug on QT interval in 14 days before surgery (TCA); beta antagonist, anti-arrhythmic, the calcium channel blocker) ; QTc more than 440 m/s; The existence of branches blocks, arrhythmia (preexitation syndrome) ; Structural heart disease.; electrolyte imbalance; hyper or hypothyroid patients 7. Extreme Obesity BMI 30 >; Diabetic neuropathy; Any non- sinus rhythm in EKG; A history of sensitivity to propofol, egg and soy. 18 years 50 years Both R 94.3 Electrocardiogram [ECG][EKG] Prevention In intervention group we use alfentanil 20-25 microgram/kg in induction and with rate of 0.5-2 microgram/kg/min in maintenance .In control group remifentanil is use with dose of 1-2 microgram/kg in induction and infused with rate of 0.2-0.25 microgram/kg/min in maintenance of anesthesia. QT interval. Timepoint: Prioperative /Six times. Method of measurement: EKG. Heart Rate Monitoring. Timepoint: Six Times Perioperative. Method of measurement: EKG. Vice Chancellor for Research, Shiraz University of Medical Sciences Approved 2013-10-08 Ethic Committee of Shiraz University Of Medical Sciences Central Building of Shiraz University Of Medical Sciences , Zand street Shiraz Iran (Islamic Republic of)