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IRCT2014041917026N1 IRCT 2014-04-19 Shahid sadoughi university of medical science, Yazd Cefazolin injection in off-pump CABG Prophylactic effect of bolus and continuous Cefazolin injection in off-pump CABG 2012-03-20 anticipated 141 Complete https://irct.ir/trial/15764 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2 Infection after cardiac surgery. Intervention 1: In Bolus group, for patients undergoing Off- Pump Coronary Artery Bypass Graft surgery. Patients in this group received 2g of Cefazolin as a starting dose, 30 minutes before incision. Then 1g of Cefazolin were administered at 3, 11 and 19 hours after starting dose respectively .therefore, overall 5gr cefazolin administered intravenously .after surgery,we survey clinical examinations and paraclinical tests .then we follow –up patients during one month about post-operative infections. Intervention 2: In continuous group, for patients undergoing Off- Pump Coronary Artery Bypass Graft surgery. Patients in this group received 2g of Cefazolin as a starting dose, 30 minutes before incision. Then 3g of Cefazolin continuously infused during 24 hours. Therefore, overall 5gr cefazolin administered intravenously .after surgery,we survey clinical examinations and paraclinical tests .then we follow –up patients during one month about post-operative infections.
public Seyed Khalil Forouzannia
Afshar hospital-Jomhori Blvd,yazd
Yazd Iran (Islamic Republic of) +98 35 1523 1421 drforouzan_nia@yahoo.com Shahid Sadoughi University of Medical Sciences, Yazd, Iran scientific Seyed Khalil Forouzannia
Afshar hospital-Jomhori Blvd,yazd
Yazd Iran (Islamic Republic of) +98 35 1523 1421 drforouzan_nia@yahoo.com Shahid Sadoughi University of Medical Sciences, Yazd, Iran Iran (Islamic Republic of) Inclusion criteria: patients without history of antibiotic therapy during the last 72 hours before surgery; no severe renal and liver failure and pregnancy; no active infection. Exclusion criteria: all patients didn't consent to use this procedure in the study. we can't use full dose of cefazolin and excise of sign of infection during administering antibiotic. no limit no limit Both B95.6,B95. Other staphylococcus as the cause of diseases classified to other chapters,Staphylococcus aureus as the cause of diseases classified to other chapters Prevention Prevention In Bolus group, for patients undergoing Off- Pump Coronary Artery Bypass Graft surgery. Patients in this group received 2g of Cefazolin as a starting dose, 30 minutes before incision. Then 1g of Cefazolin were administered at 3, 11 and 19 hours after starting dose respectively .therefore, overall 5gr cefazolin administered intravenously .after surgery,we survey clinical examinations and paraclinical tests .then we follow –up patients during one month about post-operative infections. In continuous group, for patients undergoing Off- Pump Coronary Artery Bypass Graft surgery. Patients in this group received 2g of Cefazolin as a starting dose, 30 minutes before incision. Then 3g of Cefazolin continuously infused during 24 hours. Therefore, overall 5gr cefazolin administered intravenously .after surgery,we survey clinical examinations and paraclinical tests .then we follow –up patients during one month about post-operative infections. Infection. Timepoint: One month. Method of measurement: Clinical evidence and paraclinical lab. Shahid sadoughi university of medical science, Yazd Approved 2010-09-23 Yazd Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences Shahid Ghandi Blv- Ebne Sina Ave Yazd Iran (Islamic Republic of)