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IRCT2014041317246N1 IRCT 2014-04-23 Vice Chancellor for Research and Technology Development-Ahwaz Jondishapur University of Medical Sci The Effect of Sertraline In Treatment Of Schizophrenia Evaluation of Typical Antipsychotic Augmentation with Sertraline in Reduction of Negative Symptoms in patients with Schizophrenia in Ahwaz Golestan Hospital 2012-04-20 anticipated 30 Complete https://irct.ir/trial/15907 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A schizophrenia. Intervention 1: Sertraline, tab 50 mg, oral, once a day, for 6 weeks. Intervention 2: Placebo, tab 50 mg, oral, once a day, for 6 weeeks.
public Dr. Seyed Moammad Seyed Ghafari Dezfuli
Ahwaz Jondishapur University of Medical Sciences, Golestan Blvd
Ahwaz Iran (Islamic Republic of) 6481958956 +98 61 1336 7543 raz.s@ajums.ac.ir Ahwaz Jondishapur University of Medical Sciences scientific Somayeh Raz
Ahwaz Jondishapur University of Medical Sciences, Golestan Blvd
Ahwaz Iran (Islamic Republic of) 6481958956 +98 61 1336 7543 raz.s@ajums.ac.ir Ahwaz Jondishapur University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria for this study are as follows: schizophrenia - a negative score more than 15 in PANSS; no liver disease; not treated with ECT in the past six months; during illness for over one year; aged between 21 to 63 years old. The Exclusion criteria are: depression; mental retardation; schizoaffective disorder; bipolar disorder; a neurological disorder such as epilepsy, Parkinson's disease; a risky physical illness such as cardiac ischemia or heart failure; use of antidepressants or lithium for whatever reason; Leisure drug; drug abuse within one recent month (except nicotine and caffeine); extrapyramidal side effects; deafness or dumbness active suicidal or homicidal thoughts; pregnant or lactating women; at least 3 months have passed since the last time the use of long-acting antipsychotics; drugs with a history of hypersensitivity or serious interest in the study; the patient withdrew from the study and side effects. 21 years 63 years Both F20 The schizophrenic disorders are characterized in general by fundamental and characteristic distortions of thinking and perception, and affects that are inappropriate or blunted. Clear consciousness and intellectual capacity are usually maintained although Treatment - Drugs Placebo Sertraline, tab 50 mg, oral, once a day, for 6 weeks Placebo, tab 50 mg, oral, once a day, for 6 weeeks Emotional withdrawal. Timepoint: Before intervention,1 week after intervention, 3 weeks after intervention, 6 weeks after intervention. Method of measurement: PANSS(Positive and Negative Symptom Scale). Social withdrawal. Timepoint: Before intervention, 1 week after intervention, 3 weeks after intervention, 6 weeks after intervention. Method of measurement: PANSS(Positive and Negative Symptom Scale). Blunted affect. Timepoint: Before intervention,1 week after intervention, 3 weeks after intervention, 6 weeks after intervention. Method of measurement: PANSS(Positive and Negative Symptom Scale). Other negative symptoms. Timepoint: Before intervevtion, 1 week after intervention, 3 weeks after intervention, 6 weeks after intervention. Method of measurement: PANSS(Positive and Negative Symptom Scale). Side effects. Timepoint: One week after intervention,3 weeks after intervention,6 weeks after intervention. Method of measurement: Interview with patient. Vice Chancellor for Research and Technology Development-Ahwaz Jondishapur University of Medical Sci Approved 2011-07-27 Ahwaz Jondishapur University of Medical Sciences Ahwaz Jondishapur University of Medical Sciences, Golestan Blvd Ahwaz Iran (Islamic Republic of)