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IRCT138811082016N3 IRCT 2010-02-20 Oral and Dental Research Center and Vice-Chancellor for Research of Kerman University of Medical Sci Comparison the effect of pretreatment with lbuprofen, Indomethacin, and placebo on postoperative pain of mandibular molars with irreversible pulpitis. Comparison the effect of pretreatment with lbuprofen, Indomethacin, and placebo on postoperative pain of mandibular molars with irreversible pulpitis. 2009-05-18 anticipated 150 Complete https://irct.ir/trial/1613 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 1 Postoperative pain. Intervention 1: Ibuprofen, 1 capsule of 600 mg, 1 hour before injection of the local anesthetic. Intervention 2: Indomethacin, 1 capsule of 75 mg,1 hour before the local anesthetic injection)1 hour before injection of the local anesthetic. Intervention 3: Placebo: 1 capsule contain 500 mg lactos mono hydrate,1 hour before the local anesthetic injection)1 hour before injection of the local anesthetic.
public Nozar Nakhaee
Tahmasbabad cross, Jahad Street, Vice Chancellor for Research Building
Kerman Iran (Islamic Republic of) 76175 +98 34 1226 3815 nakhaeen@yahoo.com Kerman University of Medical Sciences scientific Masoud Parirokh
Endodontic Department, Kerman dental School, Shafa street
Kerman Iran (Islamic Republic of) 76175 +98 34 1245 7931 M_Parirokh@kmu.ac.ir, masoudparirokh@gmail.com Kerman University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Age more than 18 years, no contraindications to taking either Ibuprofen or Indomethacin (history of any allergic reaction to aspirin, NSAIDS, or Lidocaine with Epinephrine, nasal polyp, history of peptic ulcers or GI bleeding, pregnancy and lactation, renal or hepatic disease), no history of GI disorders or ulcer, having no serious systemic disease. Exclusion criteria: no response to cold test, having sensitivity to percussion and palpation, having radiographic changes such as PDL widening, lack of vital pulp in coronal pulp chamber access cavity preparation, the teeth with large restoration, teeth with evidence of crack in their crown, presence of periapical radiolucency, internal resorption or calcification, and also taking narcotic drugs or analgesic drugs in recent 12 hours before treatment. 18 years 100 years Both KO4 Diseases of pulp and periapical tissues Treatment - Drugs Treatment - Drugs Placebo Ibuprofen, 1 capsule of 600 mg, 1 hour before injection of the local anesthetic Indomethacin, 1 capsule of 75 mg,1 hour before the local anesthetic injection)1 hour before injection of the local anesthetic Placebo: 1 capsule contain 500 mg lactos mono hydrate,1 hour before the local anesthetic injection)1 hour before injection of the local anesthetic Postoperative pain. Timepoint: 6, 12, 24, and 48 hours after the procedure. Method of measurement: Using Heft-Parker -Visual Analogue Scale (VAS). Oral and Dental Research Center and Vice-Chancellor for Research of Kerman University of Medical Sci Approved 2009-05-18 The Ethic Committee of Kerman University of Medical Science Vice-chancellor for Research, Kerman University of Medical Sciences, Tahmaseb-abad cross, Jahad Street, Kerman Iran (Islamic Republic of)