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IRCT2014061718124N1 IRCT 2015-06-21 Vice chancellor for research, Qazvin University of Medical Sciences The consideration of the effectiveness of licorice root extract adding to triple therapy regime of Helicobacter Pylori Comparison the eradication rate of Helicobacter pylori (HP) between standard triple therapy regime and licorice root extract adding to triple therapy regime in patients with helicobacter pylori infection 2015-06-19 anticipated 120 Complete https://irct.ir/trial/16530 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Helicobacter pylori infection. Intervention 1: Clarithromycin (500 mg twice a day) + Amoxicillin (1 gr twice a day) + Omeprazole (20 mg twice a day) for 2 weeks. After finishing the main period of treatment they receive maintaining 4 weeks by omeprazole only. Intervention 2: Intervention group: licorice root extracts ( D-Reglis 1 tab twice a day) adding to Clarithromycin (500 mg twice a day) + Amoxicillin (1 gr twice a day) + Omeprazole (20 mg twice a day) for 2 weeks. After finishing the main period of treatment they receive maintaining 4 weeks by omeprazole only.
public Dr. Sedighe Reisian
Metabolic Diseases Research Center, Bu-ali Sina Hospital, Bu-ali Sina St, Qazvin
Qazvin Iran (Islamic Republic of) +98 28 3336 0084 ahmohammadi@qums.ac.ir; SRMDFM@gmail.com Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran scientific Dr. Sedighe Reisian
Metabolic Diseases Research Center, Bu-ali Sina Hospital, Bu-ali Sina St, Qazvin
Qazvin Iran (Islamic Republic of) +98 28 3336 0084 ahmohammadi@qums.ac.ir; SRMDFM@gmail.com Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Iran (Islamic Republic of) Inclusion criteria to study: if all patients during endoscopic procedure with have positive rapid urease test (RUT), providing that not having the following condition: pregnancy؛ Previous usage Antiacid or bismuth during recent a month ؛ Gastrointestinal (GI) bleeding or any complication of peptic ulcer disease (PUD) ؛ the usage of alcohol or substance ؛ advanced chronic disease: Diabetes mellitus, Hypertension, Cirrhosis, Cerebrovascular attack, Coronary artery disease & gastric cancer. Exclusion criteria from study: lack of willingness to continue the treatment؛ lack of willingness to complete the period of treatment ؛suffering the illness that needs to consume another antibiotic or non steroidal anti inflammatory drugs (NSAIDs) . no limit no limit Both B98.0 Helicobacter pylori Treatment - Drugs Treatment - Drugs Clarithromycin (500 mg twice a day) + Amoxicillin (1 gr twice a day) + Omeprazole (20 mg twice a day) for 2 weeks. After finishing the main period of treatment they receive maintaining 4 weeks by omeprazole only Intervention group: licorice root extracts ( D-Reglis 1 tab twice a day) adding to Clarithromycin (500 mg twice a day) + Amoxicillin (1 gr twice a day) + Omeprazole (20 mg twice a day) for 2 weeks. After finishing the main period of treatment they receive maintaining 4 weeks by omeprazole only Stool antigen of HP. Timepoint: Two weeks after ending period of treatment. Method of measurement: Laboratoriaf. Vice chancellor for research, Qazvin University of Medical Sciences Approved 2015-01-08 Ethics committee of Qazvin University of Medical Sciences Vice chancellor for research, Qazvin University of Medical Sciences, Shahid Bahonar Blvd., Qazvin, iran Qazvin Iran (Islamic Republic of)