IRCT2016052318210N7 IRCT 2017-09-10 Iran University of Medical Science Treatment of burn scars using Ablative CO2 fractional Laser and topical rapamycin (sirolimus) Treatment of burn scars using Ablative CO2 fractional Laser and topical rapamycin (sirolimus) 2017-08-23 anticipated 60 Complete https://irct.ir/trial/16592 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: 60 patients(men and women) will divide by computer table of random numbers to three (equal 20 patients in each) groups. N/A Burn NOS. Intervention 1: Intervention in first group is CO2 Fractional laser, on burn scars. Device will set with skin types of patients, anatomic place and scars color and depth. laser will applied in three sections monthly. Intervention 2: Intervention in second group is Rapamycin Cream. patients will treat with Rapamycin 1% Cream for 12 weeks. Intervention 3: Intervention in third group is combination therapy of CO2 Fractional laser(on burn scars that will applied in three sections monthly) added with Rapamayci 1% Cream.