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IRCT2014070518358N1 IRCT 2014-08-01 Vice chancellor for research of Gonabad University of Medical Sciences Comparsion the effect of local application of parsley (petroselinium crispum) with hydroquinone cream on reduction the severity of epidermal melasma Comparsion the effect of local application of parsley (petroselinium crispum) with hydroquinone cream on reduction the severity of epidermal melasma: A randomized clinical trial 2014-07-23 anticipated 70 Complete https://irct.ir/trial/16669 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 epidermal melasma. Intervention 1: Intervention group will be received parsley tail((20 g parsley for 5 minutes in a liter of boiling water, brewed, smooth and leave to cool) to 8 weeks topically once at night. Intervention 2: Control group will be received hydroquinone cream to 8 weeks to receive Thin layer and topically once at night.
public Vahide Ramezani
Gonabad University of Medical Sciences, Next to the Asian Road
Gonabad Iran (Islamic Republic of) +98 53 3722 3028 ramezani.v@gmu.ac.ir Gonabad University of Medical Sciences scientific Doctor Shahla Khosravan
Gonabad University of Medical Sciences, Next to the Asian Road
Gonabad Iran (Islamic Republic of) +98 53 3722 3028 Khosravan@gmu.ac.ir Gonabad University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Women 50-15 years old (childbearing age); willingness to cooperate in the project; having of epidermal melasma, non-pregnant; Not lactating, not using anti-smudge drugs in the past 30 days , non-contraceptive therapy during the study;No history of epilepsy, liver, thyroid and asthma diseases, no history of allergy to hydroquinone, the lack of any kind of sensitivity to the families Apiaceae plants such as carrots, celery and parsley; not employed in occupations requiring long-term exposure to sunlight (farmers and laborers); Exclusion criteria: pregnancy occurs; sensitivity to hydrocarbons and parsley ; diseases affecting the severity of skin disease and treatment interaction, unwillingness to continue treatment. 15 years 50 years Female L81.1 Chloasma Treatment - Other Treatment - Drugs Intervention group will be received parsley tail((20 g parsley for 5 minutes in a liter of boiling water, brewed, smooth and leave to cool) to 8 weeks topically once at night. Control group will be received hydroquinone cream to 8 weeks to receive Thin layer and topically once at night. Epidermal melasma. Timepoint: before and after intervention. Method of measurement: The melasma severity index and wood lamp. Vice chancellor for research of Gonabad University of Medical Sciences Approved 2014-06-25 Ethics Committee of Gonabad University of Medical Sciences Gonabad University of Medical Sciences, Next to the Asian Road Gonabad Iran (Islamic Republic of)