IRCT2014071418482N1 IRCT 2014-09-26 Tehran University of Medical Science effect of N-acetylcysteine in the treatment of peritoneal dialysis and hemodialysis patients comparison of the effectiveness of adding N-acetylcysteine to current standard treatment with standard treatment alone on improving residual renal function in chronic peritoneal and hemodialysis patients 2014-08-17 anticipated 60 Complete https://irct.ir/trial/16752 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 chronic kidney disease stage 5. Intervention 1: Control group received only standard treatment including antihypertensive drugs, vitamin B, statin, asprin for a period of three month. Intervention 2: Intervention group received eff tab NAC 1200 mg BD other than standard treatment (including antihypertensive drugs, vitamin B, statin, asprin) for three month.

public Dr mahsa abbaszadeh

Keshavarz Blvd., Imam khomeini hospital

Tehran Iran (Islamic Republic of) +98 21 6119 2679 mahsa.abbaszadeh@yahoo.com Tehran University of Medical Science scientific Dr Farrokhlagha Ahmadi

Nephrology Reaserch Center, Imam Khomeini Hospital, Keshavarz Blvd.

Tehran Iran (Islamic Republic of) +98 21 6119 2679 ahmadifa@sina.tums.ac.ir Tehran University of Medical Science Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: treating with dialysis for more than 3 months ;having more than 100 mL urine in 24 hours. Exclusion Criteria: treating with dialysis for less than 3 months; having acute renal failure; being currently treated with antioxidants such as vitamins E, C.; being anuric (less than 100 mL urine in 24 hours). 18 years 80 years Both N18.5 Chronic kidney disease, stage 5 Treatment - Drugs Treatment - Drugs Control group received only standard treatment including antihypertensive drugs, vitamin B, statin, asprin for a period of three month. Intervention group received eff tab NAC 1200 mg BD other than standard treatment (including antihypertensive drugs, vitamin B, statin, asprin) for three month. 24hr urine volume. Timepoint: days 0, 15, 30, 45, 60, 75, 90. Method of measurement: measuring 24hr urine volume with graded container. Glomerular filtration rate (GFR). Timepoint: before study (day 0)and at the end of study (day 90). Method of measurement: 24hr urine volume test and evaluating mean of urea and creatinin clearance according to formula in the questionaire. KT/V. Timepoint: before study (day 0) and at the end of study (day 90). Method of measurement: measuring urea before and after dialysis. Fasting plasma glucose. Timepoint: before study and monthly till the end of the study. Method of measurement: laboratory. Gastrointestinal complication (nausea, vomiting, diarrhea). Timepoint: patients visits. Method of measurement: asking from paitients. Tehran University of Medical Science Approved 2014-01-26 Tehran University of Medical Science Tehran University of Medical Science, Poursina street, Qods street, Keshavarz Blvd. Tehran Iran (Islamic Republic of)