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IRCT2014080218659N1 IRCT 2015-09-07 Vice Chancellor for Research, Yazd Shahid Sadoughi University of Medical Sciences Effect of propolis on diabetes mellitus The effect of propolis tablet on glycemic control, lipid profile and insulin resistance in comparison with placebo in patients with type 2 diabetes mellitus 2014-09-23 anticipated 67 Complete https://irct.ir/trial/16858 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: A double blind study. Patients and researcher are blind about intervention and placebo groups. 2 type 2 diabetes. Intervention 1: Patients in intervention group receive propolis tabletes,3 times a day, for 12 weeks.Each tablet contains 300 mg propolis. Intervention 2: Patients in control group, receive placebo tablets 3 times a day for 12 weeks.
public Nazli Samadi Bilehsavar
Department of Health, Imam Reza building, Student Blvd, Imam Hossein Square
Yazd Iran (Islamic Republic of) 89165887 +98 35 3624 0691 nazlisamadi510@gmail.com Shahid Sadooghi University of Medical Sciences and Health scientific Hassan Mozaffari Khosravi
Department of Health, Imam Reza building, Student Blvd, Imam Hossein Square
Yazd Iran (Islamic Republic of) 89165887 +98 35 3624 0691 mozaffari.kh@gmail.com Shahid Sadooghi University of Medical Sciences and Health Services in Yazd Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: patients with type 2 diabetes mellitus, diagnosed 5-10 years ago, under treatment with oral hypoglycemic agents. Exclusion criteria: pregnancy, lactation, insulin therapy, any other diseases such as autoimmune, intestinal, liver, thyroid and cardiovascular diseases, vitamin and mineral supplementation, history of dermal or digestive hypersensitivity to propolis, any severe respiratory disease (such as asthma, chronic bronchitis), report of side effects of propolis tablets. 25 years 75 years Both E11 Non-insulin-dependent diabetes mellitus Treatment - Drugs Treatment - Drugs Patients in intervention group receive propolis tabletes,3 times a day, for 12 weeks.Each tablet contains 300 mg propolis. Patients in control group, receive placebo tablets 3 times a day for 12 weeks Fasting Blood Glucose. Timepoint: Before and after intervention. Method of measurement: Enzymatic method (mg/dl). Fasting insulin. Timepoint: Before and after intervention. Method of measurement: ELISA(mU/l). Triglyceride. Timepoint: Before and after intervention. Method of measurement: Enzymatic method (mg/dl). Total cholesterol. Timepoint: Before and after intervention. Method of measurement: Enzymatic method (mg/dl). LDL-C. Timepoint: before and after intervention. Method of measurement: Friedewald formula (mg/dl). HDL-C. Timepoint: before and after intervention. Method of measurement: Precipitation(mg/dl). Insulin resistance, sensitivity. Timepoint: Before and after intervention. Method of measurement: Software. HA1C. Timepoint: The baseline and three months after the intervention. Method of measurement: Turbidometry. Vice Chancellor for Research, Yazd Shahid Sadoughi University of Medical Sciences Approved 2014-11-26 Yazd Shahid Sadoghi University of Medical Sciences Ethics Committee University of Medical Sciences and Health Services-Bahonar sq-YAZD Yazd Iran (Islamic Republic of)