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IRCT2014081718834N1 IRCT 2015-02-07 Vice chancellor for research of Shahid Sadoughi Dental Faculty Effect of phenytoin mucoadhesive paste 1% on periodontal parameters Evaluation of effect of phenytoin mucoadhesive paste 1% after non-surgical therapy on improvement of periodontal status in moderate to severe chronic periodontitis patients 2015-01-30 anticipated 20 Complete https://irct.ir/trial/16962 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Chronic periodontitis. Intervention 1: In control side after the first phase of periodontal treatment was accomplished which including oral hygiene instructions, scaling and root planning, instructions about the application of the paste was given to all patients. This placebo paste is contained of 50 grams of mucoadhesive polymers including carbomer 934 and (Hydroxypropyl)methyl cellulose (1:1 w/w). subsequently, the mixed powders were gradually livigated with 50 grams of liquid paraffin.patients should use the paste on the buccal surface of determined side twice a day after tooth-brushing and using dental floss for a week. Intervention 2: After the first phase of periodontal treatment was accomplished which including oral hygiene instructions, scaling and root planning, instructions about the application of the paste was given to all patients.To prepare Phenytoin paste one gram of phenytoin powder was mixed with 50 grams of mucoadhesive polymers including carbomer 934 and (Hydroxypropyl)methyl cellulose (1:1 w/w). subsequently, the mixed powders were gradually livigated with 50 grams of liquid paraffin.patients should use the paste on the buccal surface of determined side twice a day after tooth-brushing and using dental floss for a week.
public Dr Nahid Nasrabadi
Department of Periodontics, Shahid Sadoughi Dental Faculty, Dahey Fajr BLV, Imam Ave
Yazd Iran (Islamic Republic of) +98 35 1621 2623 nasrabadi.nahid@gmail.com Dental school of Yazd scientific Dr Nahid Nasrabadi
Department of Periodontics, Shahid Sadoughi Dental Faculty, Dahey Fajr BLV, Imam Ave
Yazd Iran (Islamic Republic of) +98 35 1621 2623 nasrabadi.nahid@yahoo Dental school of Yazd Iran (Islamic Republic of) Inclusion criteria were considered as follows: having ability to read and write, no systemic diseases such as diabetes or heart disease, not taking medications affecting periodontium (anti- hypertensives, immune suppressants and anticonvulsants), not being pregnant, no smoking, no traumatic occlusion, no history of antibiotic therapy within the last three months, having at least two similar teeth on each sextants without any decays or restorations and filling informed consent form. In addition we consulted with internist about any drug interactions to phenytoin in patients of our study. The exclusion criteria were considered as follows: 1) inappropriate control plaque during the study. 2) irregular use of pastes on the basis of given instructions 3) not taking part in following up appointments. no limit no limit Both K05.3 Chronic periodontitis Placebo Treatment - Drugs In control side after the first phase of periodontal treatment was accomplished which including oral hygiene instructions, scaling and root planning, instructions about the application of the paste was given to all patients. This placebo paste is contained of 50 grams of mucoadhesive polymers including carbomer 934 and (Hydroxypropyl)methyl cellulose (1:1 w/w). subsequently, the mixed powders were gradually livigated with 50 grams of liquid paraffin.patients should use the paste on the buccal surface of determined side twice a day after tooth-brushing and using dental floss for a week. After the first phase of periodontal treatment was accomplished which including oral hygiene instructions, scaling and root planning, instructions about the application of the paste was given to all patients.To prepare Phenytoin paste one gram of phenytoin powder was mixed with 50 grams of mucoadhesive polymers including carbomer 934 and (Hydroxypropyl)methyl cellulose (1:1 w/w). subsequently, the mixed powders were gradually livigated with 50 grams of liquid paraffin.patients should use the paste on the buccal surface of determined side twice a day after tooth-brushing and using dental floss for a week. Pocket depth. Timepoint: 4 weeeks. Method of measurement: milimeters by Williams’s periodontal probe. Bleeding on probing. Timepoint: 4 weeks. Method of measurement: percentage. Modified gingival index. Timepoint: 4 weeks. Method of measurement: grading by observation. Vice chancellor for research of Shahid Sadoughi Dental Faculty Approved 2014-05-11 Ethics committee of Shahid Sadoughi University of Medical Sciences of Yazd Shahid Bahonar Square, Yazd, Iran Yazd Iran (Islamic Republic of)