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IRCT2014082518922N1 IRCT 2014-12-06 Vice Chancellor for research, Kashan University of Medical Sciences Effect of Folic acid supplementation on the therapeutic regimen for major depressive disorder Effect of Folic acid supplementation on response to the standard treatment in patients with major depressive disorder. 2013-11-06 anticipated 90 Complete https://irct.ir/trial/17035 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Major depression. Intervention 1: Folic acid tablet, one half of 5 mg tablets, once per day for 8 weeks. Intervention 2: Tablets without the active ingredient with the same size and shape of Folic acid tablet, a half tablet daily, for 8 weeks.
public Dr. Narges Gholampour
Psychiatry group, Kargarnejad Hospital, Ghotbe Ravandi Blvd.
Kashan Iran (Islamic Republic of) +98 31 5554 0036 gholampour@kaums.ac.ir Kashan University of Medical Sciences scientific Dr. Narges Gholampour
Psychiatry group, Kargarnejad Hospital, Ghotbe Ravandi Blvd.
Kashan Iran (Islamic Republic of) +98 31 5554 0036 gholampour@kaums.ac.ir Kashan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: To have a definite diagnosis of major depressive disorder according to the DSM-IV-TR criteria; Being between 20 and 50 years old; To get the minimum score of 12 from the BDI 2 scoring system; Having stopped taking any other antidepressant medications since 4 weeks before starting folic acid; Patients who sign the written informed consent after being provided with the detailed information about the study; Not having anemia based on a Complete Blood Count (CBC) test; The absence of pregnancy; No alcohol or substance use in 6 months prior to the study; The absence of manic episodes; The absence of psychotic symptoms; The absence of mental retardation; Depression not due to a general medical condition or substance; The absence of any severe or chronic physical illnesses. Exclusion criteria: Having any acute and severe medical conditions; The incidence of any severe psychiatric disorders (suicidal thoughts, psychotic symptoms, manic phase symptoms, etc.); Failure to follow-up for at least 4 weeks; The concomitant use of other psychotropic drugs; The incidence of severe complications during treatment. 20 years 50 years Both F32 Depressive episode Treatment - Drugs Placebo Folic acid tablet, one half of 5 mg tablets, once per day for 8 weeks Tablets without the active ingredient with the same size and shape of Folic acid tablet, a half tablet daily, for 8 weeks Depression severity. Timepoint: 4, 6 and 8 weeks after starting the treatment. Method of measurement: The Beck Depression Inventory 2nd Edition. Vice Chancellor for research, Kashan University of Medical Sciences Approved 2013-10-26 Kashan University of Medical Sciences Vice chancellor for research, Kashan Medical Sciences complex, Ghotbe Ravandi Blvd. Kashan Iran (Islamic Republic of)