IRCT2015021819037N6 IRCT 2015-03-05 Investigator Comparison of the effect of Ketofol with Propofol on patients' vital sign changes during laparotomy Comparison of the effect of Ketofol (combination of Ketamin and Propofol) with Propofol during anesthesia induction on hemodynamic changes in patients undergo laparotomy 2014-09-16 anticipated 90 Complete https://irct.ir/trial/17130 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: In this study the candidate patients for laparotomy will be randomly divided into one of the groups (trial or control) by usage of colored carts. 2-3 Condition 1: Heart rate instability due to anesthesia. Condition 2: Blood pressure instability due to anesthesia. Intervention 1: First intervention group (trial): Receiving handmade drug, Ketofol: 10 ml Propofol solution (10 mg/ml, from Fresenius Kabi drug manufacturing company, Germany) with 10 ml Ketamin solution (50 mg/ml, from Rotxmedica drug manufacturing company, Germany). One dose of the combined solution was admitted for the patients intravenously for anesthesia induction (1.5 mg/kg). Intervention 2: Second intervention group (control): Receiving Propofol solution (10 mg/ml, from Fresenius Kabi drug manufacturing company, Germany). One dose of this drug was admitted for the patients intravenously for anesthesia induction (1.5 mg/kg).