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IRCT2014090719072N1 IRCT 2015-02-11 Isfahan University of Medica Science ,Deputy Director of Research and Development The Effect of Dietary Approach to Stop Hypertension (DASH) on Insulin Resistance The Effect of DASH (Dietary Approach to Stop Hypertension) on IRS1 and PPARҮ2 Genes Expression in Obese Women 2013-03-31 anticipated 60 Complete https://irct.ir/trial/17147 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Basic scienece. N/A healthy obese volunteer. Intervention 1: The intervention group will prescribe DASH diet that is rich in fruits, vegetables, whole grains, and low fat dairy products, and low in saturated fat, total fat, cholesterol, refined grains and sweets .The diets would be prescribed weekly, and an exchange list would be given to each patient for exchanging food items and counting the calories. A nutritionist will teach subjects how to apply the exchange list and write food diaries. Every participant will bring her 3-day diet records every month, and the dairies would be reviewed by N4 nutritional software and their compliance would be assessed by analyzing the three food record diaries monthly and the attendance at meetings and monthly visits. Intervention 2: The control group was recommended to “eat as usual” and received healthy dietary advises which would be printed on a paper .Every participant will bring his 3-day diet records every month, and the dairies would be reviewed by NUTRITIONIST 4 software and their diet was assessed by analyzing the three food record diaries.
public Dr Mohammad Hasan Entezari
iNutrition School, Isfahan University of Medical Science, Hezarjerib Street, Azadi Squre, Isfahan.
Isfahan Iran (Islamic Republic of) +98 31 3792 2776 entezari@hlth.mui.ac.ir Isfahan University of Medical Science scientific Dr Mohammad hasan Entezari
Nutrition School, Isfahan University of Medical Science, Hezarjerib Street, Azadi Squre, Isfahan.
ISFAHAN Iran (Islamic Republic of) +98 31 3792 2767 entezari@hlth.mui.ac.ir Isfahan University of Medical Science Iran (Islamic Republic of) Inclusion Criteria: female; Body Mass Index above 30; age 20-50; absence of cardiovascular; hepatic; renal; thyroid; diabetes; rheumatoid arthritis; lupus; severe infection; trauma; allergy disease; don't use of multivitamin and mineral or omega-3 fatty acids supplements; don't regular use of antacid drugs containing magnesium and calcium ; consumption Aspirin and Non Steroid Anti Inflammation; and anti-depressant and hormone drugs; lack of pregnancy and breastfeeding; don't get weight loss in 6 months (more than 1 kg; don't use of tobacco and alcohol. Exclusion criteria: Failure to follow the prescribed diet( energy intake is different more than 300 calorie from prescribed as regard to food record analysis ), if weight change is more than 5%, diagnosis one of mentioned disease in inclusion criteria and using of chemical or herbal medicines during the study. 20 years 49 years Female E66.9 Simple obesity NOS Lifestyle Lifestyle The intervention group will prescribe DASH diet that is rich in fruits, vegetables, whole grains, and low fat dairy products, and low in saturated fat, total fat, cholesterol, refined grains and sweets .The diets would be prescribed weekly, and an exchange list would be given to each patient for exchanging food items and counting the calories. A nutritionist will teach subjects how to apply the exchange list and write food diaries. Every participant will bring her 3-day diet records every month, and the dairies would be reviewed by N4 nutritional software and their compliance would be assessed by analyzing the three food record diaries monthly and the attendance at meetings and monthly visits. The control group was recommended to “eat as usual” and received healthy dietary advises which would be printed on a paper .Every participant will bring his 3-day diet records every month, and the dairies would be reviewed by NUTRITIONIST 4 software and their diet was assessed by analyzing the three food record diaries. PPAR gamma Gene Expression. Timepoint: Before Intervention and After 3 Months. Method of measurement: Real Time Polymerase Chain Reaction. IRS1 Gene Expression. Timepoint: Before Intervention and After 3 Months. Method of measurement: Real Time Polymerase Chain Reaction. Insulin resistance. Timepoint: Before Intervention and After 3 Months. Method of measurement: Hemostatic Model Assessment(HOMA). Weight. Timepoint: Before Study and After 3 Months. Method of measurement: Scale. Fasting Sugar. Timepoint: Before Study and After 3 Months. Method of measurement: Caloremetric. Fasting Insulin. Timepoint: Before Study and After 3 Month. Method of measurement: Elisa Method. Isfahan University of Medica Science ,Deputy Director of Research and Development Approved 2013-07-06 Isfahan University OF Medical Science Nutrition School, Isfahan University of Medical Science, Hezarjerib Street, Azadi Squre, Isfahan. Isfahan Iran (Islamic Republic of)