IRCT2014091919199N2 IRCT 2015-04-12 Arak University of Medical Sciences, Vice chancellor for research Effect of N-acetyl cysteine on hepatitis risk reduction after anesthesia Comparison of N-acetyl cysteine vs saline on liver function on general anesthesia with isoflurane in Arak Vali-e-Asr hospital 2014-04-15 anticipated 68 Complete https://irct.ir/trial/17238 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: In a double-blind clinical trial ,patients were randomly divided in two groups,According to medical ethics will obtain consent to enter the study of patients.Data collector will not inform the patient information and patient groups will not inform about their position in the group. 3 liver toxicity. Intervention 1: In intervention group patients will receive 150 mg/kg N-Acetyl cysteine with 250 ml normal saline in single IV dose and isoflurane will be used for maintenance anesthesia. We injected above mentioned solution before induction.All patients will pre-oxygenated with 100% oxygen.Patients will take Fentanyl 2mc/kg, 3-6 mg/kg sodium thiopental ( logi Chem UK)and 0/5 mg/kg Atracurium(Alborz darou).All patients will take 1 mg/kg fentanyl and 0/2 mg/kg atracurium during anesthesia every 40 minutes.Trial group will receive 12/5 mg/kg N-acetyl cysteine during surgery. Intervention 2: In control group patients will receive only 250 ml normal salinein single IV dose and isoflurane will used for maintenance anesthesia.we injected above solution before induction.All patients will pre-oxygenated with 100% oxygen.Patients will take Fentanyl 2mc/kg, 3-6 mg/kg sodium thiopental ( logi Chem UK)and 0/5 mg/kg Atracurium(Alborz darou).All patients every 40 minutes will take 1 mg/kg fentanyl and 0/2 mg/kg atracurium during anesthesia.