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IRCT201211062106N4 IRCT 2013-02-25 Isfahan University of Medical Sciences, Vice Challenry Itraconazole and clinical and radiologic findings in patients with recurrent chronic rhinosinusitis and nasal polyposis Effectiveness of Itraconazole on clinical symptoms and radiologic findings in patients with recurrent chronic rhinosinusitis and nasal polyposis 2011-11-01 anticipated 22 Complete https://irct.ir/trial/1727 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 2 Condition 1: nasal polyposis. Condition 2: Chronic rhinitis. Itraconazole capsule of 100 mg, twice per day prescribed for 3 months.(Rose Daru- Tehran- Iran)..
public Akram Fereidani
Al-Zahra hospital, Sofe St.
Isfahan Iran (Islamic Republic of) +98 31 1668 5555 a.fereidani@gmail.com Isfahan University of Medical Sciences scientific Mostafa Hashemi
Kashani hospital, Kashani St.
Isfahan Iran (Islamic Republic of) +98 31 1668 5555 mostafahashemi60@gmail.com Isfahan University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) The inclusion criteria contained patients at least 15 years old without history of hepatic disease and heart failure; without allergy to Itraconazole, and usage of interacting medications (cisapride, dofetilide, ergot derivatives, levomethadyl lovastatin, midazolam (oral), nisoldipine, pimozide, quinidine, simvastatin, or triazolam). Exclusion criteria of the study were no compliance for follow up; side effects of Itraconazole like rising in hepatic enzyme; nausea, vomiting or starting a new treatment during the study. 15 years no limit Both J33 J32 Nasal polyp Chronic rhinitis Treatment - Drugs Itraconazole capsule of 100 mg, twice per day prescribed for 3 months.(Rose Daru- Tehran- Iran). Severity of rhinorrhea, nasal obstruction, hyposmia, dyspnea. Timepoint: 0, 1st, 3rd and 6th months. Method of measurement: Asking the patient about the score of none, mild, moderate and severe. Quality of life. Timepoint: 0,1st, 3rd and 6th months. Method of measurement: SNOT-20. Serum IgE. Timepoint: 0 and 3rd months. Method of measurement: Unit. Score of CT scan. Timepoint: 0 and 3rd months. Method of measurement: Lund-Mackay scale. Side effects like elevated liver enzyme, diarrhea and nausea. Timepoint: 0,1st, 3rd and 6th months. Method of measurement: Ask a patient. Isfahan University of Medical Sciences, Vice Challenry Approved 2011-11-01 Isfahan University of Medical sciences, Vice Challenry Hezar Jarib St, Isfahan Isfahan Iran (Islamic Republic of)