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IRCT2014100419396N1 IRCT 2015-02-09 Hormozgan University of Medical Sciences effectiveness of Tranexamic acid in blood loss during and after cesarean section Investigating the effectiveness of Tranexamic acid in blood loss during and after cesarean section 2013-04-22 anticipated 200 Complete https://irct.ir/trial/17342 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A caesarean section. Intervention 1: In the intervention group, with the help of an anesthesiologist, 20 minutes before the cesarean surgery 10 milligrams of Tranexamic acid for each kilogram of body mass combined with 200 milliliters of normal saline will be slowly injected within 5 minutes. Intervention 2: Patients in the control group, will receive only 200 milliliters of normal saline within 5 minutes.
public Azin Alavi
Shariati Hospital, Hormozgan University of Medical Sciences
Bandar Abbas Iran (Islamic Republic of) +98 76 3333 2424 azin_alavi@yahoo.com Shariati Hospital, Hormozgan University of Medical Sciences scientific Azin Alavi
Shariati hospital, Hormozgan University of Medical Sciences
Bandar Abbas Iran (Islamic Republic of) +98 76 3333 2424 azin_alavi@yahoo.com Shariati hospital, Hormozgan University of Medical Sciences Iran (Islamic Republic of) All women between 20 to 40 years of age who were in their 37th to 40th week of pregnancy and had opted for a cesarean surgery entered the study. The following were excluded: those with an experience of twinning; placenta abnormalities; severe pre-eclampsia; macrosomy; polyhydramnios; previous cesarean or abdominal surgeries; kidney, brain, blood or liver disorders, coagulopathy; anemia; thrombophilia; thromboembolic disorders; allergy to Tranexamic acid. In addition, patients whose BMI was higher than 30 were excluded from the study. 20 years 40 years Female 82 Single delivery by caesarean section Treatment - Drugs Placebo In the intervention group, with the help of an anesthesiologist, 20 minutes before the cesarean surgery 10 milligrams of Tranexamic acid for each kilogram of body mass combined with 200 milliliters of normal saline will be slowly injected within 5 minutes Patients in the control group, will receive only 200 milliliters of normal saline within 5 minutes The amount of the blood loss. Timepoint: The amount of the blood lost would be estimated 2 hours after the delivery (based on the difference of the weight of the tampon used). At the outset of the surgery, a tampon would be inserted into the vagina, the difference of its weight before the surgery and 2 hours after the surgery will be calculated. Method of measurement: The amount of blood loss would be estimated through Gai et al.’s method:. Hormozgan University of Medical Sciences Approved 2013-05-08 Hormozgan University of Medical Sciences vice chancellor for research and technology, Shahid Mohamadi Hospital Bandar Abbas Iran (Islamic Republic of)