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IRCT2014101719470N2 IRCT 2015-01-16 Shiraz University of Medical Sciences The Effects of Pregabalin on Agitation and Pain after Cardiac Surgery RASS (Richmond agitation sedation scale),VAS(Visual analogue scale) The Effects of Pregabalin on Agitation and Pain after Coronary Artery Bypass Graft Surgery 2015-02-01 anticipated 94 Complete https://irct.ir/trial/17388 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Coronary Artery Bypass Graft. Intervention 1: Patients in the intervention group received 150 mg pregabalin, 2 hours before surgery and 75 mg pregabalin at the first, second and third days after surgery in the hours of 9 am and 9 pm . Intervention 2: Patients in the control group received one capsule placebo , 2 hours before surgery and at the first, second and third days after surgery in the hours of 9 am and 9 pm.
public Sudabeh Emami
Anesthesiology Department, Shahid Faghihi Hospital, Zand street
Shiraz Iran (Islamic Republic of) +98 71 3235 7282 emami_s@sums.ac.ir Shiraz University of Medical Sciences scientific Reza Jouybar
Anesthesiology office, Namazi Hospital
Shiraz Iran (Islamic Republic of) +98 71 3647 4270 joybarr@sums.ac.ir Shiraz University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients who undergo coronary artery bypass graft surgery. exclusion criteria: EF < 35%, Cr > 1.5, BMI > 35, chronic alcohol consumers, drug addicts, epileptic patients, patients with insulin dependent diabetes mellitus ', recent use of gabapentin, uncontrolled blood pressure, liver failure, the sensitivity of the Pregabalin, return to the operating room during the study period, the patient's re-intubation during the first 3 days after the surgery, mortality during the first 3 days. no limit no limit Male 125.1 Atherosclerotic Heart Disease Treatment - Drugs Placebo Patients in the intervention group received 150 mg pregabalin, 2 hours before surgery and 75 mg pregabalin at the first, second and third days after surgery in the hours of 9 am and 9 pm . Patients in the control group received one capsule placebo , 2 hours before surgery and at the first, second and third days after surgery in the hours of 9 am and 9 pm Pain. Timepoint: Twice at Three Days after Surgery. Method of measurement: ,VAS(Visual Analogue Scale. Agitation. Timepoint: Twice at Three Days after Surgery. Method of measurement: Richmond agitation sedation scale. Shiraz University of Medical Sciences Approved 2010-09-23 Ethic Committee of Shiraz University Of Medical Sciences Central Building of Shiraz University of Medical Sciences, Zand Street Shiraz Iran (Islamic Republic of)