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IRCT2016081319470N37 IRCT 2016-09-04 Vice Chancellor for Research, Shiaz University of Medical Sciences The effect of Ascorbic Acid infusion during kidney transplantation on post-operative renal function in the Kidney Transplantation Patients The effect of Ascorbic Acid infusion during renal transplantation on post-operative renal function status in the Kidney Transplantation Patients 2015-03-21 anticipated 64 Complete https://irct.ir/trial/17411 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: In order to randomization, by using the site www.randomization.com twenty-frequency (permutation) binary of A and B were made then draw the group receiving vitamin C (A or B) is determined. To assign patients to one of the two groups two patients who are supposed to use a donor kidneys become a pair. Of the individual pairs that his/her last name comes first in alphabetical view is selected as the upper part of the B-A block.if the alphabetical view of the initial word of the family name was similar then we will use the alphabetical order of the first name and if similar initial word of the father name and at least national code will be used. After obtaining consent patients without the knowledge that which of the syringe is vitamin C or saline divided into two groups of case and control. (Syringes with volume of 50 cc and same shape. And a person who is unaware of the study prepares Syringes with labeled A, B on which they put at the disposal of researchers.). 2-3 Kidney transplant. Intervention 1: patients in group A received vitamin C 100 mg / kg (total volume with normal saline 50 cc) within 6 hours. Intervention 2: Patients in the control group received a 50 cc normal saline within 6 hours.
public Seeyed Javad Enjoo
Anesthesiology Department,Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) +98 71 3647 4270 enjoosj@yahoo.com Shiraz University of Medical Sciences scientific Dr Mohamad bagher Khosravi
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) +98 71 3647 4270 khosravimb@sums.ac.ir Shiraz University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients who are undergoing kidney transplantation. Exclusion criteria: drug sensitivity; cardiomyopathy; chronic obstructive pulmonary disease (COPD) and respiratory diseases; intraoperative hypotension; inotrope requirement during the surgery. no limit 60 years Both Z94.0 Kidney transplant status Treatment - Drugs Placebo patients in group A received vitamin C 100 mg / kg (total volume with normal saline 50 cc) within 6 hours Patients in the control group received a 50 cc normal saline within 6 hours. To check the MDA (Malondialdehyde). Timepoint: In 3 stages (at the beginning of the operation, 1 and 2 hours after declamping of renal artery). Method of measurement: by spectrophotometry. To check the TAC (total antioxidant status). Timepoint: In 3 stages (at the beginning of the operation, 1 and 2 hours after declamping of renal artery). Method of measurement: spectrophotometry. Graft function of kidney monitoring after transplantation. Timepoint: daily for 5 days in the ICU and one mounth after kidney transpalantation. Method of measurement: measurement of BUN, creatinine, GFR and need for hemodialysis. Vice Chancellor for Research, Shiaz University of Medical Sciences Approved 2016-03-05 Ethics committee of Shiraz University of Medical Sciences Vice Chancellor of Research, Shiaz University of Medical Sciences, 7th floor, Central Building of Shiraz University of Medical Sciences, Zand Street Shiraz Iran (Islamic Republic of)