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IRCT2014110419808N1 IRCT 2014-11-28 Hamadan University of Medical Science Study of Effects of Repetitive Transcranial Magnetic Stimulation on cognition of Refractory Obsessive Compulsive Disorder Patients Study of Cognitive Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients of Refractory Obsessive Compulsive Disorder 2014-11-22 anticipated 10 Complete https://irct.ir/trial/17618 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment. N/A refractory obsessive compulsive disorder. Intervention 1: Intervention (refractory transcranial magnetic stimulation (rTMS)): high frequency left (HFL) stimulation will initially be applied at 20 Hz, in 25 trains of 1.5 second duration with a 30 second interval between trains and at 100% of the resting motor threshold (RMT) for a total of 25 minutes of stimulation; Then following this, high frequency right (HFR) stimulation will be applied at the same parameters. Therefore a total of 50 minutes of stimulation will be delivered. Intervention 2: Control (Sham condition): Sham stimulation will be made at the site of active treatment but with only "the side edge" resting on the scalp. It will be administered as high frequency left (HFL) and high frequency right (HFR) for total of 50 minutes, but with the coil angled 45-90 degrees away from the skull in a single-wing tilt position. This method produces sound and somatic sensation (e.g., contraction of scalp muscles) like those with active stimulation but with minimal direct brain effects. Participants will remain blind to the treatment condition.
public Dr Mehran Shaygan Fard
Farshchian Hospital, Mirzade eshghi st
Hamedan Iran (Islamic Republic of) +98 81 3827 4192 mshayganfard@yahoo.com Research center for behavioral disorders and substance abuse, Hamadan University of Medical Science scientific Dr Mohammad Haghighi
Farshchian Hospital, Mirzade Eshghi st
Hamedan Iran (Islamic Republic of) +98 81 3827 4192 haghighi@umsha.ac.ir Research center for behavioral disorders and substance abuse, Hamadan university of medical sciences Iran (Islamic Republic of) Inclusion Criteria: have a DSM-IV-TR diagnosis of OCD; ages between 18 and 65 years old; have failed to achieve a clinical response, or did not tolerate, at least 3 separate antidepressant trials of sufficient dose (included clomipramine) and CBT for at least 10 weeks; score of greater than or equal to 17 on the Y-BOCS. Exclusion Criteria: a history of DSM-IV-TR substance dependence in the last 6 months or DSM-IV-TR substance abuse in the last month; a concomitant major unstable medical or neurologic illness or have had a history of seizures; acutely suicidal; being pregnant; metal implants; if they are currently (or in the last 4 weeks) taking more than lorazepam 2 mg daily (or equivalent), monoamine oxidase inhibitors, and/or bupropion (due to its associated increased risk for seizures); Education lower than 2nd class of guidance school 18 years 65 years Both F42.2 Mixed obsessional thoughts and acts Treatment - Devices Treatment - Devices Intervention (refractory transcranial magnetic stimulation (rTMS)): high frequency left (HFL) stimulation will initially be applied at 20 Hz, in 25 trains of 1.5 second duration with a 30 second interval between trains and at 100% of the resting motor threshold (RMT) for a total of 25 minutes of stimulation; Then following this, high frequency right (HFR) stimulation will be applied at the same parameters. Therefore a total of 50 minutes of stimulation will be delivered. Control (Sham condition): Sham stimulation will be made at the site of active treatment but with only "the side edge" resting on the scalp. It will be administered as high frequency left (HFL) and high frequency right (HFR) for total of 50 minutes, but with the coil angled 45-90 degrees away from the skull in a single-wing tilt position. This method produces sound and somatic sensation (e.g., contraction of scalp muscles) like those with active stimulation but with minimal direct brain effects. Participants will remain blind to the treatment condition. Rate of cognition in refractory OCD. Timepoint: after 10th, 20th sessions of rTMS or sham. Method of measurement: PASSAT, Digit symbol, Digit Span. Hamadan University of Medical Science Approved 2014-10-06 Hamadan University of Medical Sciences Shahid Fahmideh Street, Hamedan Hamedan Iran (Islamic Republic of)