Objectives: Evaluation effect of topical 6.3.3 penicillin powder in the treatment of oral aphthous ulcer.
Design: Penicillin and placebo powder put in the same pockets, then coded based on random numbers table and given to Patients.
Setting and conduct: After comments and complete the consent form by volunteers, powder four times (one hour after meals and before bed) is used and by an applicator is placed on a wound as a single layer.
Patients examine in days zero, three, six and eight the followings:
A) Pain, including Mild: Can you eat food, moderate: be able to eat more than half the food, Severe: Can not eat more than half of food.
B) Wound size: The largest and smallest lesion diameter was measured with a caliper, multiply and is used to evaluate the wound.
C) Complications: Burning, pain, erythematic, inflammation.
Participants including major eligibility: Persons 15-45 years with a history of aphthous stomatitist and oral mucosa is easily accessible location. People with a history of penicillin allergy ،cephalosporin and beta-lacteal antibiotics or ulcer were healing less than five days were excluded from the study.
Interventions: 6.3.3 penicillin powder and placebo, as a topical applicator (0.2 mg) Outcome variables: size reduction, pain relief, reduction of oral aphthous improvement, complications.