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IRCT2016040920175N1 IRCT 2016-06-14 Esfahan University of Medical Sciences The effect of sildenafil in cystic fibrosis disease Evaluation of the sildenafil efficacy in exercise test and spirometric value in CF 2016-02-21 anticipated 20 Complete https://irct.ir/trial/17888 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Cystic fibrosis. Tablet sildenafil; first: 1mg/kg/day in 3 times for 1 week and then 1mg/kg/dose 3 times in day for 3 months..
public Dr. Mohsen reisi
Emam-Hosein Hospital, Emam-Khomeini Street-Esfahan
Esfahan Iran (Islamic Republic of) +98 31 3387 9300 mohsenreisi@med.mui.ac.ir Esfahan University of Medical Sciences scientific Dr. Mohsen reisi
Emam-Hosein Hospital, Emam-Khmeini Street, Esfahan
Esfahan Iran (Islamic Republic of) +98 31 3458 8601 mohsenreisi@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Confirmed CF with respiratory; gastrointestinal or urogenital symptom with positive test for CF in two times; (CL>60) male and female more than 8 years with potency of doing spirometry; stable vital sign without upper or lower respiratory tract infection; FEV1>50%. Exclusion criteria: History of sensitivity to sildenafil or daily usage of systemic corticostroid or ibuprofen; LFT>3*normal; biliary cirhosis; portal hypertention; heart diseases such as aortic stenosis, arrhythmia, coronary artery disaeaes; neurological or hematologic or renal disaeas; takingof alfa blocker or nitrate or calcium blocker or CYP3A4 inhibitor such as ketoconazole or erythromycin; history of migraine; druge sensitivity or side effect or no patient inclination to continuation. 8 years no limit Both E84 Mucoviscidosis Treatment - Drugs Tablet sildenafil; first: 1mg/kg/day in 3 times for 1 week and then 1mg/kg/dose 3 times in day for 3 months. FEV1/FVC. Timepoint: Before the study and 3months after the start. Method of measurement: Spirometry. FEV1. Timepoint: Befor the study and 3 months after the stsrt. Method of measurement: Spirometry. FEF25-75. Timepoint: Before the study and 3months after the start. Method of measurement: Spirometry. Walking tolerance. Timepoint: Before the study and 3montha after the start. Method of measurement: Minute, ET test. Drug sensitivity. Timepoint: Weekly. Method of measurement: History. Esfahan University of Medical Sciences Approved 2015-02-18 Esfahan University of Medical Sciences Hezar-Jerib Street, Darvazeh-Shiraz Esfahan Iran (Islamic Republic of)